Digoxin-Quinidine Interaction

Rune Dahlqvist; Gunnar Ejvinsson; Karin Schenck-Gustafsson; W. David Hager; Paul Fenster; Michael Mayersohn; Donald Perrier

doi:10.1056/NEJM197909273011317

Digoxin-Quinidine Interaction

Rune Dahlqvist
, Gunnar Ejvinsson
, Karin Schenck-Gustafsson
, W. David Hager
, Paul Fenster
, Michael Mayersohn
, Donald Perrier

Research output: Contribution to journal › Letter › peer-review

9 Scopus citations

Abstract

To the Editor: We should like to comment on the paper by Hager et al.¹ concerning the interaction between quinidine and digoxin. Since we described this interaction²^,³ continued research by us⁴ and others¹^,⁵ has shown a marked decrease in renal digoxin clearance by quinidine. In our series 17 patients on maintenance digoxin therapy were given quinidine for atrial fibrillation. Digoxin plasma levels increased in all. In five of these patients renal digoxin clearance was determined and found to be decreased by 57 to 84 per cent, to an average of 39 ml per minute. This reduction seems too large to.

Original language	English (US)
Pages (from-to)	727-728
Number of pages	2
Journal	New England Journal of Medicine
Volume	301
Issue number	13
DOIs	https://doi.org/10.1056/NEJM197909273011317
State	Published - Sep 27 1979
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "Digoxin-Quinidine Interaction",

abstract = "To the Editor: We should like to comment on the paper by Hager et al.1 concerning the interaction between quinidine and digoxin. Since we described this interaction2,3 continued research by us4 and others1,5 has shown a marked decrease in renal digoxin clearance by quinidine. In our series 17 patients on maintenance digoxin therapy were given quinidine for atrial fibrillation. Digoxin plasma levels increased in all. In five of these patients renal digoxin clearance was determined and found to be decreased by 57 to 84 per cent, to an average of 39 ml per minute. This reduction seems too large to.",

author = "Rune Dahlqvist and Gunnar Ejvinsson and Karin Schenck-Gustafsson and Hager, \{W. David\} and Paul Fenster and Michael Mayersohn and Donald Perrier",

year = "1979",

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day = "27",

doi = "10.1056/NEJM197909273011317",

language = "English (US)",

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T1 - Digoxin-Quinidine Interaction

AU - Dahlqvist, Rune

AU - Ejvinsson, Gunnar

AU - Schenck-Gustafsson, Karin

AU - Hager, W. David

AU - Fenster, Paul

AU - Mayersohn, Michael

AU - Perrier, Donald

PY - 1979/9/27

Y1 - 1979/9/27

N2 - To the Editor: We should like to comment on the paper by Hager et al.1 concerning the interaction between quinidine and digoxin. Since we described this interaction2,3 continued research by us4 and others1,5 has shown a marked decrease in renal digoxin clearance by quinidine. In our series 17 patients on maintenance digoxin therapy were given quinidine for atrial fibrillation. Digoxin plasma levels increased in all. In five of these patients renal digoxin clearance was determined and found to be decreased by 57 to 84 per cent, to an average of 39 ml per minute. This reduction seems too large to.

AB - To the Editor: We should like to comment on the paper by Hager et al.1 concerning the interaction between quinidine and digoxin. Since we described this interaction2,3 continued research by us4 and others1,5 has shown a marked decrease in renal digoxin clearance by quinidine. In our series 17 patients on maintenance digoxin therapy were given quinidine for atrial fibrillation. Digoxin plasma levels increased in all. In five of these patients renal digoxin clearance was determined and found to be decreased by 57 to 84 per cent, to an average of 39 ml per minute. This reduction seems too large to.

UR - https://www.scopus.com/pages/publications/0018717220

UR - https://www.scopus.com/pages/publications/0018717220#tab=citedBy

U2 - 10.1056/NEJM197909273011317

DO - 10.1056/NEJM197909273011317

M3 - Letter

C2 - 481475

AN - SCOPUS:0018717220

SN - 0028-4793

VL - 301

SP - 727

EP - 728

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 13

ER -

Digoxin-Quinidine Interaction

Abstract

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