TY - JOUR
T1 - Digoxin-Quinidine Interaction
AU - Dahlqvist, Rune
AU - Ejvinsson, Gunnar
AU - Schenck-Gustafsson, Karin
AU - Hager, W. David
AU - Fenster, Paul
AU - Mayersohn, Michael
AU - Perrier, Donald
PY - 1979/9/27
Y1 - 1979/9/27
N2 - To the Editor: We should like to comment on the paper by Hager et al.1 concerning the interaction between quinidine and digoxin. Since we described this interaction2,3 continued research by us4 and others1,5 has shown a marked decrease in renal digoxin clearance by quinidine. In our series 17 patients on maintenance digoxin therapy were given quinidine for atrial fibrillation. Digoxin plasma levels increased in all. In five of these patients renal digoxin clearance was determined and found to be decreased by 57 to 84 per cent, to an average of 39 ml per minute. This reduction seems too large to.
AB - To the Editor: We should like to comment on the paper by Hager et al.1 concerning the interaction between quinidine and digoxin. Since we described this interaction2,3 continued research by us4 and others1,5 has shown a marked decrease in renal digoxin clearance by quinidine. In our series 17 patients on maintenance digoxin therapy were given quinidine for atrial fibrillation. Digoxin plasma levels increased in all. In five of these patients renal digoxin clearance was determined and found to be decreased by 57 to 84 per cent, to an average of 39 ml per minute. This reduction seems too large to.
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U2 - 10.1056/NEJM197909273011317
DO - 10.1056/NEJM197909273011317
M3 - Letter
C2 - 481475
AN - SCOPUS:0018717220
SN - 0028-4793
VL - 301
SP - 727
EP - 728
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 13
ER -