Difficulties in Studying Silent Ischemia

Guy L. Reed, Kim A. Eagle, Sidney O. Gottlieb, Myron L. Weisfeldt, Pamela Ouyang, E. David Mellits, Gary Gerstenblith

Research output: Contribution to journalLetterpeer-review


To the Editor: The report by Gottlieb and his colleagues (May 8 issue)* is an important contribution to the study of silent ischemia. However, there are several important methodologic and statistical flaws that tend to invalidate the authors' conclusion that “silent myocardial ischemia appears to identify a subset of patients who are at increased risk for early unfavorable outcomes.” In evaluating the clinical importance of silent ischemia, the authors use coronary-artery bypass surgery and percutaneous transluminal coronary angioplasty as unfavorable outcomes. They indicate that “revascularization” was performed in patients who had at least two episodes of angina at rest with.

Original languageEnglish (US)
Pages (from-to)1094-1095
Number of pages2
JournalNew England Journal of Medicine
Issue number17
StatePublished - Oct 23 1986
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Difficulties in Studying Silent Ischemia'. Together they form a unique fingerprint.

Cite this