TY - JOUR
T1 - Differing patterns of cognitive dysfunction and heart rate reactivity in chemically-intolerant individuals with and without lifestyle changes
AU - Bell, Iris R.
AU - Bootzin, Richard R.
AU - Schwartz, Gary E.R.
AU - Baldwin, Carol M.
AU - Ballesteros, Faith
N1 - Funding Information:
Iris R. Bell is affiliated with the Departments of Psychiatry, Psychology, and Family and Community Medicine, University of Arizona Health Sciences Center, and also with the Department of Psychiatry, Tucson Veterans Affairs Medical Center, Tucson, AZ. Richard R. Bootzin is affiliated with the Department of Psychology, University of Arizona Health Sciences Center, Tucson, AZ. Gary E. R. Schwartz is affiliated with the Departments of Psychiatry, Psychology, and Nerology, University of Arizona Health Sciences Center, Tucson, AZ. Carol M. Baldwin is affiliated with the Departments of Psychology, Medicine, and the Respiratory Sciences Center, University of Arizona Health Sciences Center, Tucson, AZ. Faith Ballesteros is affiliated with the Department of Psychology, and the Respiratory Sciences Center, University of Arizona Health Sciences Center, Tucson, AZ. Address correspondence to: Iris R. Bell, MD, PhD, Department of Psychiatry, Tucson Veterans Affairs Medical Center, 3601 South 6th Avenue, MS 4-116A, Tucson, AZ 85723 (E-mail: [email protected]). This study was supported by a grant from the Wallace Genetic Foundation.
PY - 1999
Y1 - 1999
N2 - The purpose of the present study was to compare specific neuropsychological, psychological, and family history patterns, as well as cardiovascular reactivity of three community-recruited groups of nonsmoking, nonalcoholic middle-aged individuals with and without the symptom of intolerance to low levels of environmental chemicals (CI). CI is a common symptom in chronic fatigue syndrome and fibromyalgia. The groups included: (i) CI who had made associated lifestyle changes because of the CI (CI/LSC); (ii) CI who had not made such changes (CI); and (iii) normals without CI (N). All subjects underwent an evaluation session followed by two laboratory cognitive and psychophysiological test sessions one week apart. The CI/LSC diverged from the other groups in exhibiting poorer performance on the Continuous Visual Memory Test (CVMT) in terms of more false alarms and fewer correct hits, but normal performance on a visuospatial test of divided attention (DAT). In contrast, the CI group showed progressively poorer performance on the DAT with practice, but were like the N on the CVMT. The CI group showed a complex sensitization (amplification) of heart rate response to the DAT over time. In addition, the CI/LSC had the highest rate of family histories of alcohol problems and of attention deficit disorder, as well as of antihypertensive medication treatment and self-reported past emotional/physical abuse. Taken together, the data suggest that individuals with CI comprise a heterogeneous population requiring careful definition of subtypes for future studies.
AB - The purpose of the present study was to compare specific neuropsychological, psychological, and family history patterns, as well as cardiovascular reactivity of three community-recruited groups of nonsmoking, nonalcoholic middle-aged individuals with and without the symptom of intolerance to low levels of environmental chemicals (CI). CI is a common symptom in chronic fatigue syndrome and fibromyalgia. The groups included: (i) CI who had made associated lifestyle changes because of the CI (CI/LSC); (ii) CI who had not made such changes (CI); and (iii) normals without CI (N). All subjects underwent an evaluation session followed by two laboratory cognitive and psychophysiological test sessions one week apart. The CI/LSC diverged from the other groups in exhibiting poorer performance on the Continuous Visual Memory Test (CVMT) in terms of more false alarms and fewer correct hits, but normal performance on a visuospatial test of divided attention (DAT). In contrast, the CI group showed progressively poorer performance on the DAT with practice, but were like the N on the CVMT. The CI group showed a complex sensitization (amplification) of heart rate response to the DAT over time. In addition, the CI/LSC had the highest rate of family histories of alcohol problems and of attention deficit disorder, as well as of antihypertensive medication treatment and self-reported past emotional/physical abuse. Taken together, the data suggest that individuals with CI comprise a heterogeneous population requiring careful definition of subtypes for future studies.
KW - Chemical intolerance
KW - Divided attention
KW - Family alcoholism
KW - Heart rate
KW - Hypertension
KW - Multiple chemical sensitivity
KW - Neural sensitization
KW - Visual memory
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U2 - 10.1300/J092v05n02_02
DO - 10.1300/J092v05n02_02
M3 - Article
AN - SCOPUS:0033023756
SN - 1057-3321
VL - 5
SP - 3
EP - 25
JO - Journal of Chronic Fatigue Syndrome
JF - Journal of Chronic Fatigue Syndrome
IS - 2
ER -