Differential vulnerability of thalamic nuclei in multiple sclerosis

Simon Blyau; Ismail Koubiyr; Manojkumar Saranathan; Pierrick Coupé; Mathilde Deloire; Julie Charré-Morin; Aurore Saubusse; Bei Zhang; Brian Rutt; Vincent Dousset; Bruno Brochet; Aurélie Ruet; Thomas Tourdias

doi:10.1177/13524585221114247

Differential vulnerability of thalamic nuclei in multiple sclerosis

Simon Blyau
, Ismail Koubiyr
, Manojkumar Saranathan
, Pierrick Coupé
, Mathilde Deloire
, Julie Charré-Morin
, Aurore Saubusse
, Bei Zhang
, Brian Rutt
, Vincent Dousset
, Bruno Brochet
, Aurélie Ruet
, Thomas Tourdias

Medical Imaging

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences.

Original language	English (US)
Pages (from-to)	295-300
Number of pages	6
Journal	Multiple Sclerosis Journal
Volume	29
Issue number	2
DOIs	https://doi.org/10.1177/13524585221114247
State	Published - Feb 2023

Keywords

MRI
differential vulnerability
segmentation
thalamic nuclei
thalamus
volumetry

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Differential vulnerability of thalamic nuclei in multiple sclerosis",

abstract = "Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences.",

keywords = "MRI, differential vulnerability, segmentation, thalamic nuclei, thalamus, volumetry",

author = "Simon Blyau and Ismail Koubiyr and Manojkumar Saranathan and Pierrick Coup{\'e} and Mathilde Deloire and Julie Charr{\'e}-Morin and Aurore Saubusse and Bei Zhang and Brian Rutt and Vincent Dousset and Bruno Brochet and Aur{\'e}lie Ruet and Thomas Tourdias",

note = "Publisher Copyright: {\textcopyright} The Author(s), 2022.",

year = "2023",

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doi = "10.1177/13524585221114247",

language = "English (US)",

volume = "29",

pages = "295--300",

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T1 - Differential vulnerability of thalamic nuclei in multiple sclerosis

AU - Blyau, Simon

AU - Koubiyr, Ismail

AU - Saranathan, Manojkumar

AU - Coupé, Pierrick

AU - Deloire, Mathilde

AU - Charré-Morin, Julie

AU - Saubusse, Aurore

AU - Zhang, Bei

AU - Rutt, Brian

AU - Dousset, Vincent

AU - Brochet, Bruno

AU - Ruet, Aurélie

AU - Tourdias, Thomas

N1 - Publisher Copyright: © The Author(s), 2022.

PY - 2023/2

Y1 - 2023/2

N2 - Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences.

AB - Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences.

KW - MRI

KW - differential vulnerability

KW - segmentation

KW - thalamic nuclei

KW - thalamus

KW - volumetry

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SP - 295

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JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 2

ER -

Differential vulnerability of thalamic nuclei in multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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