Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences.
- differential vulnerability
- thalamic nuclei
ASJC Scopus subject areas
- Clinical Neurology
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Blyau, S. (Creator), Koubiyr, I. (Creator), Saranathan, M. (Creator), Coupé, P. (Creator), Deloire, M. (Creator), Charré-Morin, J. (Creator), Saubusse, A. (Creator), Zhang, B. (Creator), Rutt, B. (Creator), Dousset, V. (Creator), Brochet, B. (Creator), Ruet, A. (Creator) & Tourdias, T. (Creator), SAGE Journals, 2022