Differential vulnerability of thalamic nuclei in multiple sclerosis

Simon Blyau, Ismail Koubiyr, Manojkumar Saranathan, Pierrick Coupé, Mathilde Deloire, Julie Charré-Morin, Aurore Saubusse, Bei Zhang, Brian Rutt, Vincent Dousset, Bruno Brochet, Aurélie Ruet, Thomas Tourdias

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalMultiple Sclerosis Journal
Issue number2
StatePublished - Feb 2023


  • MRI
  • differential vulnerability
  • segmentation
  • thalamic nuclei
  • thalamus
  • volumetry

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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