Differential sorting and post-secretory targeting of proteins in parasitic invasion

Huân M. Ngô; Heinrich C. Hoppe; Keith A. Joiner

doi:10.1016/S0962-8924(99)01698-0

Differential sorting and post-secretory targeting of proteins in parasitic invasion

Huân M. Ngô, Heinrich C. Hoppe, Keith A. Joiner

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

Toxoplasma gondii uses a highly coordinated arsenal of three structurally and biochemically distinct secretory granules to invade and develop in a wide range of host cells. Proteins of these secretory granules are sorted to strategic subcellular locations using distinctive sorting signals and are then triggered differentially for exocytosis. These secreted proteins are subsequently targeted and inserted into membrane domains.

Original language	English (US)
Pages (from-to)	67-72
Number of pages	6
Journal	Trends in Cell Biology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/S0962-8924(99)01698-0
State	Published - Feb 1 2000
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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title = "Differential sorting and post-secretory targeting of proteins in parasitic invasion",

abstract = "Toxoplasma gondii uses a highly coordinated arsenal of three structurally and biochemically distinct secretory granules to invade and develop in a wide range of host cells. Proteins of these secretory granules are sorted to strategic subcellular locations using distinctive sorting signals and are then triggered differentially for exocytosis. These secreted proteins are subsequently targeted and inserted into membrane domains.",

author = "Ng{\^o}, {Hu{\^a}n M.} and Hoppe, {Heinrich C.} and Joiner, {Keith A.}",

note = "Funding Information: We thank Isabelle Coppens, Anthony Sinai and Gianluca Gallo for their helpful suggestions for this review. K.A.J. is a Burroughs-Wellcome Investigator in Molecular Parasitology and H.M.N. is supported by NIH postdoctoral grants 5T32AI07404 and 5F32AI10044.",

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doi = "10.1016/S0962-8924(99)01698-0",

language = "English (US)",

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T1 - Differential sorting and post-secretory targeting of proteins in parasitic invasion

AU - Ngô, Huân M.

AU - Hoppe, Heinrich C.

AU - Joiner, Keith A.

N1 - Funding Information: We thank Isabelle Coppens, Anthony Sinai and Gianluca Gallo for their helpful suggestions for this review. K.A.J. is a Burroughs-Wellcome Investigator in Molecular Parasitology and H.M.N. is supported by NIH postdoctoral grants 5T32AI07404 and 5F32AI10044.

PY - 2000/2/1

Y1 - 2000/2/1

N2 - Toxoplasma gondii uses a highly coordinated arsenal of three structurally and biochemically distinct secretory granules to invade and develop in a wide range of host cells. Proteins of these secretory granules are sorted to strategic subcellular locations using distinctive sorting signals and are then triggered differentially for exocytosis. These secreted proteins are subsequently targeted and inserted into membrane domains.

AB - Toxoplasma gondii uses a highly coordinated arsenal of three structurally and biochemically distinct secretory granules to invade and develop in a wide range of host cells. Proteins of these secretory granules are sorted to strategic subcellular locations using distinctive sorting signals and are then triggered differentially for exocytosis. These secreted proteins are subsequently targeted and inserted into membrane domains.

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DO - 10.1016/S0962-8924(99)01698-0

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JO - Trends in Cell Biology

JF - Trends in Cell Biology

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ER -

Differential sorting and post-secretory targeting of proteins in parasitic invasion

Abstract

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