TY - JOUR
T1 - Differential regulation of EGFR-MAPK signaling by deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) in colon cancer.
AU - Centuori, Sara M.
AU - Martinez, Jesse D.
N1 - Funding Information:
Acknowledgments We are thankful to Cecil J. Gomes, BS, who assisted in the editing of this manuscript and also to Josh Brownlee, BS, for assistance with production of 3-dimensional figures. This work was supported by the RO1 CA129688 and the minority supplement CA129688 S1 awarded by the National Institute of Health, to Jesse D. Martinez.
PY - 2014/10
Y1 - 2014/10
N2 - A high-fat diet coincides with increased levels of bile acids. This increase in bile acids, particularly deoxycholic acid (DCA), has been strongly associated with the development of colon cancer. Conversely, ursodeoxycholic acid (UDCA) may have chemopreventive properties. Although structurally similar, DCA and UDCA present different biological and pathological effects in colon cancer progression. The differential regulation of cancer by these two bile acids is not yet fully understood. However, one possible explanation for their diverging effects is their ability to differentially regulate signaling pathways involved in the multistep progression of colon cancer, such as the epidermal growth factor receptor (EGFR)-mitogen-activated protein kinase (MAPK) pathway. This review will examine the biological effects of DCA and UDCA on colon cancer development, as well as the diverging effects of these bile acids on the oncogenic signaling pathways that play a role in colon cancer development, with a particular emphasis on bile acid regulation of the EGFR-MAPK pathway.
AB - A high-fat diet coincides with increased levels of bile acids. This increase in bile acids, particularly deoxycholic acid (DCA), has been strongly associated with the development of colon cancer. Conversely, ursodeoxycholic acid (UDCA) may have chemopreventive properties. Although structurally similar, DCA and UDCA present different biological and pathological effects in colon cancer progression. The differential regulation of cancer by these two bile acids is not yet fully understood. However, one possible explanation for their diverging effects is their ability to differentially regulate signaling pathways involved in the multistep progression of colon cancer, such as the epidermal growth factor receptor (EGFR)-mitogen-activated protein kinase (MAPK) pathway. This review will examine the biological effects of DCA and UDCA on colon cancer development, as well as the diverging effects of these bile acids on the oncogenic signaling pathways that play a role in colon cancer development, with a particular emphasis on bile acid regulation of the EGFR-MAPK pathway.
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U2 - 10.1007/s10620-014-3190-7
DO - 10.1007/s10620-014-3190-7
M3 - Review article
C2 - 25027205
AN - SCOPUS:84908503682
SN - 0163-2116
VL - 59
SP - 2367
EP - 2380
JO - Digestive diseases and sciences
JF - Digestive diseases and sciences
IS - 10
ER -