Differential localization of antigonadotropic and vasotocic activities in bovine and rat pineal

Bryant Benson; Mary Jane Matthews; Mac E. Hadley; Stephen Powers; Victor J. Hruby

doi:10.1016/0024-3205(76)90173-9

Differential localization of antigonadotropic and vasotocic activities in bovine and rat pineal

Bryant Benson, Mary Jane Matthews, Mac E. Hadley, Stephen Powers, Victor J. Hruby

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Bovine pineal glands were separated into stalk and parenchymal portions and extracted separately for both pineal antigonadotropic and neurohypophysial activities. Bioassay of these extracts localized neurohypophysial hormone activity to the stalk and antigonadotropic activity to the pineal parenchyma. Destalked rat pineals were devoid of neurohypophysial hormone activity at the concentrations employed. Whereas the injection of purified extracts containing pineal antigonadotropin reduced ventral prostate weights in mice, vasotocin was without such actions. these results fail to support pineal (parenchymal) localization of vasotocin and a reproductive role for this neurohypophysial peptide.

Original language	English (US)
Pages (from-to)	747-754
Number of pages	8
Journal	Life Sciences
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/0024-3205(76)90173-9
State	Published - Sep 1 1976

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Differential localization of antigonadotropic and vasotocic activities in bovine and rat pineal",

abstract = "Bovine pineal glands were separated into stalk and parenchymal portions and extracted separately for both pineal antigonadotropic and neurohypophysial activities. Bioassay of these extracts localized neurohypophysial hormone activity to the stalk and antigonadotropic activity to the pineal parenchyma. Destalked rat pineals were devoid of neurohypophysial hormone activity at the concentrations employed. Whereas the injection of purified extracts containing pineal antigonadotropin reduced ventral prostate weights in mice, vasotocin was without such actions. these results fail to support pineal (parenchymal) localization of vasotocin and a reproductive role for this neurohypophysial peptide.",

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T1 - Differential localization of antigonadotropic and vasotocic activities in bovine and rat pineal

AU - Benson, Bryant

AU - Jane Matthews, Mary

AU - Hadley, Mac E.

AU - Powers, Stephen

AU - Hruby, Victor J.

PY - 1976/9/1

Y1 - 1976/9/1

N2 - Bovine pineal glands were separated into stalk and parenchymal portions and extracted separately for both pineal antigonadotropic and neurohypophysial activities. Bioassay of these extracts localized neurohypophysial hormone activity to the stalk and antigonadotropic activity to the pineal parenchyma. Destalked rat pineals were devoid of neurohypophysial hormone activity at the concentrations employed. Whereas the injection of purified extracts containing pineal antigonadotropin reduced ventral prostate weights in mice, vasotocin was without such actions. these results fail to support pineal (parenchymal) localization of vasotocin and a reproductive role for this neurohypophysial peptide.

AB - Bovine pineal glands were separated into stalk and parenchymal portions and extracted separately for both pineal antigonadotropic and neurohypophysial activities. Bioassay of these extracts localized neurohypophysial hormone activity to the stalk and antigonadotropic activity to the pineal parenchyma. Destalked rat pineals were devoid of neurohypophysial hormone activity at the concentrations employed. Whereas the injection of purified extracts containing pineal antigonadotropin reduced ventral prostate weights in mice, vasotocin was without such actions. these results fail to support pineal (parenchymal) localization of vasotocin and a reproductive role for this neurohypophysial peptide.

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Differential localization of antigonadotropic and vasotocic activities in bovine and rat pineal

Abstract

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