Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae

Joe R. Delaney, Christopher Murakami, Annie Chou, Daniel Carr, Jennifer Schleit, George L. Sutphin, Elroy H. An, Anthony S. Castanza, Marissa Fletcher, Sarani Goswami, Sean Higgins, Mollie Holmberg, Jessica Hui, Monika Jelic, Ki Soo Jeong, Jin R. Kim, Shannon Klum, Eric Liao, Michael S. Lin, Winston LoHillary Miller, Richard Moller, Zhao J. Peng, Tom Pollard, Prarthana Pradeep, Dillon Pruett, Dilreet Rai, Vanessa Ros, Alex Schuster, Minnie Singh, Benjamin L. Spector, Helen Vander Wende, Adrienne M. Wang, Brian M. Wasko, Brady Olsen, Matt Kaeberlein

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Chronological aging of budding yeast cells results in a reduction in subsequent replicative life span through unknown mechanisms. Here we show that dietary restriction during chronological aging delays the reduction in subsequent replicative life span up to at least 23. days of chronological age. We further show that among the viable portion of the control population aged 26. days, individual cells with the lowest mitochondrial membrane potential have the longest subsequent replicative lifespan. These observations demonstrate that dietary restriction modulates a common molecular mechanism linking chronological and replicative aging in yeast and indicate a critical role for mitochondrial function in this process.

Original languageEnglish (US)
Pages (from-to)1006-1013
Number of pages8
JournalExperimental Gerontology
Issue number10
StatePublished - Oct 2013
Externally publishedYes


  • Caloric restriction
  • Calorie restriction
  • Chronological lifespan
  • Dietary restriction
  • Glucose
  • Mitochondria
  • Replicative lifespan

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology


Dive into the research topics of 'Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae'. Together they form a unique fingerprint.

Cite this