TY - JOUR
T1 - Dietary pattern influences breast cancer prognosis in women without hot flashes
T2 - the women's healthy eating and living trial
AU - Gold, Ellen B.
AU - Pierce, John P.
AU - Natarajan, Loki
AU - Stefanick, Marcia L.
AU - Laughlin, Gail A.
AU - Caan, Bette J.
AU - Flatt, Shirley W.
AU - Emond, Jennifer A.
AU - Saquib, Nazmus
AU - Madlensky, Lisa
AU - Kealey, Sheila
AU - Wasserman, Linda
AU - Thomson, Cynthia A.
AU - Rock, Cheryl L.
AU - Parker, Barbara A.
AU - Karanja, Njeri
AU - Jones, Vicky
AU - Hajek, Richard A.
AU - Pu, Minya
AU - Mortimer, Joanne E.
PY - 2009/1/20
Y1 - 2009/1/20
N2 - Purpose To determine whether a low-fat diet high in vegetables, fruit, and fiber differentially affects prognosis in breast cancer survivors with hot flashes (HF) or without HF after treatment. Patients and Methods A secondary analysis was conducted on 2,967 breast cancer survivors, age 18 to 70 years, who were randomly assigned between 1995 and 2000 in a multicenter, controlled trial of a dietary intervention to prevent additional breast cancer events and observed through June 1, 2006. We compared the dietary intervention group with a group who received five-a-day dietary guidelines. Results Independent of HF status, a substantial between-group difference among those who did and did not receive dietary guidelines was achieved and maintained at 4 years in intake of vegetable/fruit servings per day (54% higher; 10 v6.5 servings/d, respectively), fiber (31% higher; 25.5 v 19.4 g/d, respectively), and percent energy from fat (14% lower; 26.9% v 31.3%, respectively). Adjusting for tumor characteristics and antiestrogen treatment, HF-negative women assigned to the intervention had 31% fewer events than HF-negative women assigned to the comparison group (hazard ratio [HR] = 0.69; 95% CI, 0.51 to 0.93; P =.02). The intervention did not affect prognosis in the women with baseline HFs. Furthermore, compared with HF-negative women assigned to the comparison group, HF-positive women had significantly fewer events in both the intervention (HR = 0.77; 95% CI, 0.59 to 1.00; P =. 05) and comparison groups (HR = 0.65; 95% CI, 0.49 to 0.85; P =. 002). Conclusion A diet with higher vegetable, fruit, and fiber and lower fat intakes than the five-a-day diet may reduce risk of additional events in HF-negative breast cancer survivors. This suggestive finding needs confirmation in a trial in which it is the primary hypothesis.
AB - Purpose To determine whether a low-fat diet high in vegetables, fruit, and fiber differentially affects prognosis in breast cancer survivors with hot flashes (HF) or without HF after treatment. Patients and Methods A secondary analysis was conducted on 2,967 breast cancer survivors, age 18 to 70 years, who were randomly assigned between 1995 and 2000 in a multicenter, controlled trial of a dietary intervention to prevent additional breast cancer events and observed through June 1, 2006. We compared the dietary intervention group with a group who received five-a-day dietary guidelines. Results Independent of HF status, a substantial between-group difference among those who did and did not receive dietary guidelines was achieved and maintained at 4 years in intake of vegetable/fruit servings per day (54% higher; 10 v6.5 servings/d, respectively), fiber (31% higher; 25.5 v 19.4 g/d, respectively), and percent energy from fat (14% lower; 26.9% v 31.3%, respectively). Adjusting for tumor characteristics and antiestrogen treatment, HF-negative women assigned to the intervention had 31% fewer events than HF-negative women assigned to the comparison group (hazard ratio [HR] = 0.69; 95% CI, 0.51 to 0.93; P =.02). The intervention did not affect prognosis in the women with baseline HFs. Furthermore, compared with HF-negative women assigned to the comparison group, HF-positive women had significantly fewer events in both the intervention (HR = 0.77; 95% CI, 0.59 to 1.00; P =. 05) and comparison groups (HR = 0.65; 95% CI, 0.49 to 0.85; P =. 002). Conclusion A diet with higher vegetable, fruit, and fiber and lower fat intakes than the five-a-day diet may reduce risk of additional events in HF-negative breast cancer survivors. This suggestive finding needs confirmation in a trial in which it is the primary hypothesis.
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U2 - 10.1200/JCO.2008.16.1067
DO - 10.1200/JCO.2008.16.1067
M3 - Article
C2 - 19075284
AN - SCOPUS:58549101917
SN - 0732-183X
VL - 27
SP - 352
EP - 359
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 3
ER -