Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women

Lizbeth López-Carrillo, Brenda Gamboa-Loira, Wendy Becerra, César Hernández-Alcaraz, Raúl Ulises Hernández-Ramírez, A. Jay Gandolfi, Francisco Franco-Marina, Mariano E. Cebrián

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Introduction Concentrations of inorganic arsenic (iAs) metabolites in urine present intra- and interindividual variations, which are determined not only by the magnitude of exposure to iAs, but also by differences in genetic, environmental and dietary factors. Objective To evaluate whether differences in dietary intake of selected micronutrients are associated with the metabolism of iAs. Methods The intake of 21 micronutrients was estimated for 1027 women living in northern Mexico using a food frequency questionnaire. Concentration of urinary metabolites of iAs was determined by high performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) and the proportion of iAs metabolites was calculated (%iAs, monomethylarsonic acid [%MMA] and dimethylarsinic acid [%DMA]), as well as ratios corresponding to the first (MMA/iAs), second (DMA/MMA) and total methylation (DMA/iAs). Results After adjustment for covariates, it was found that methionine, choline, folate, vitamin B12, Zn, Se and vitamin C favor elimination of iAs mainly by decreasing the %MMA and/or increasing %DMA in urine. Conclusions Our results confirm that diet contributes to the efficiency of iAs elimination. Further studies are needed to assess the feasibility of dietary interventions that modulate the metabolism of iAs and the consequent risk of diseases related to its exposure.

Original languageEnglish (US)
Pages (from-to)445-450
Number of pages6
JournalEnvironmental Research
StatePublished - Nov 1 2016


  • Arsenic metabolism
  • Inorganic arsenic
  • Micronutrients
  • Northern Mexico

ASJC Scopus subject areas

  • Biochemistry
  • General Environmental Science


Dive into the research topics of 'Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women'. Together they form a unique fingerprint.

Cite this