TY - JOUR
T1 - Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women
AU - López-Carrillo, Lizbeth
AU - Gamboa-Loira, Brenda
AU - Becerra, Wendy
AU - Hernández-Alcaraz, César
AU - Hernández-Ramírez, Raúl Ulises
AU - Gandolfi, A. Jay
AU - Franco-Marina, Francisco
AU - Cebrián, Mariano E.
N1 - Funding Information:
This study was supported by CONACYT Fondo Sectorial de Investigación en Salud y Seguridad Social 2005-2-14373 , 2009-1-111384 y 2010-1-140962 and by The Superfund Basic Research Program Grant to the University of Arizona ( NIH ES-04940 ). The analyses for arsenic metabolites were performed by the Analytical Section of the Hazard Identification Core, College of Pharmacy, University of Arizona. We wish to acknowledge Michael Kopplin for performing the analyses and Rosa María Hernández for technical support.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Introduction Concentrations of inorganic arsenic (iAs) metabolites in urine present intra- and interindividual variations, which are determined not only by the magnitude of exposure to iAs, but also by differences in genetic, environmental and dietary factors. Objective To evaluate whether differences in dietary intake of selected micronutrients are associated with the metabolism of iAs. Methods The intake of 21 micronutrients was estimated for 1027 women living in northern Mexico using a food frequency questionnaire. Concentration of urinary metabolites of iAs was determined by high performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) and the proportion of iAs metabolites was calculated (%iAs, monomethylarsonic acid [%MMA] and dimethylarsinic acid [%DMA]), as well as ratios corresponding to the first (MMA/iAs), second (DMA/MMA) and total methylation (DMA/iAs). Results After adjustment for covariates, it was found that methionine, choline, folate, vitamin B12, Zn, Se and vitamin C favor elimination of iAs mainly by decreasing the %MMA and/or increasing %DMA in urine. Conclusions Our results confirm that diet contributes to the efficiency of iAs elimination. Further studies are needed to assess the feasibility of dietary interventions that modulate the metabolism of iAs and the consequent risk of diseases related to its exposure.
AB - Introduction Concentrations of inorganic arsenic (iAs) metabolites in urine present intra- and interindividual variations, which are determined not only by the magnitude of exposure to iAs, but also by differences in genetic, environmental and dietary factors. Objective To evaluate whether differences in dietary intake of selected micronutrients are associated with the metabolism of iAs. Methods The intake of 21 micronutrients was estimated for 1027 women living in northern Mexico using a food frequency questionnaire. Concentration of urinary metabolites of iAs was determined by high performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) and the proportion of iAs metabolites was calculated (%iAs, monomethylarsonic acid [%MMA] and dimethylarsinic acid [%DMA]), as well as ratios corresponding to the first (MMA/iAs), second (DMA/MMA) and total methylation (DMA/iAs). Results After adjustment for covariates, it was found that methionine, choline, folate, vitamin B12, Zn, Se and vitamin C favor elimination of iAs mainly by decreasing the %MMA and/or increasing %DMA in urine. Conclusions Our results confirm that diet contributes to the efficiency of iAs elimination. Further studies are needed to assess the feasibility of dietary interventions that modulate the metabolism of iAs and the consequent risk of diseases related to its exposure.
KW - Arsenic metabolism
KW - Inorganic arsenic
KW - Micronutrients
KW - Northern Mexico
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U2 - 10.1016/j.envres.2016.08.015
DO - 10.1016/j.envres.2016.08.015
M3 - Article
C2 - 27565879
AN - SCOPUS:84983465450
VL - 151
SP - 445
EP - 450
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
ER -