Dietary Inflammatory Index and Risk of Colorectal Adenoma Recurrence: A Pooled Analysis

C. L. Sardo Molmenti, S. E. Steck, C. A. Thomson, E. A. Hibler, J. Yang, N. Shivappa, H. Greenlee, M. D. Wirth, A. I. Neugut, E. T. Jacobs, J. R. Hébert

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


No studies have evaluated the association between the dietary inflammatory index (DII) and colorectal adenoma recurrence. DII scores were calculated from a baseline food frequency questionnaire. Participants (n = 1727) were 40–80 years of age, enrolled in two Phase III clinical trials, who had ≥1 colorectal adenoma(s) removed within 6 months of study registration, and a follow-up colonoscopy during the trial. Multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). No statistically significant associations were found between DII and odds of colorectal adenoma recurrence [ORs (95% CIs) = 0.93 (0.73, 1.18) and 0.95 (0.73, 1.22)] for subjects in the second and third DII tertiles, respectively, compared to those in the lowest tertile (Ptrend = 0.72). No associations were found for recurrent colorectal adenoma characteristics, including advanced recurrent adenomas, large size, villous histology, or anatomic location. While our study did not support an association between a proinflammatory diet and colorectal adenoma recurrence, future studies are warranted to elucidate the role of a proinflammatory diet on the early stages of colorectal carcinogenesis.

Original languageEnglish (US)
Pages (from-to)238-247
Number of pages10
JournalNutrition and cancer
Issue number2
StatePublished - Feb 17 2017

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research


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