Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats

Susan Sergeant, Joseph A. McQuail, David R. Riddle, Floyd H. Chilton, Steven B. Ortmeier, Jewell A. Jessup, Leanne Groban, Michelle M. Nicolle

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Fish oil (FO) mediates a number of cardioprotective benefits in patients with cardiovascular disease. In the absence of cardiovascular disease, however, the effects of FO on cardiac structure and function are not clear. In addition, it is not known if an effective dosing strategy for attenuating age-related cardiac dysfunction is also effective at limiting cognitive dysfunction. Therefore, we determined if 4 months of FO supplementation in aged rats would lessen age-related cardiac dysfunction while concomitantly preventing the cognitive decline that is normally observed in this population. The results indicate that FO initiated late in life modifies diastolic function in a small but positive way by attenuating the age-related increases in filling pressure, posterior wall thickness, and interstitial collagen without mitigating age-related deficits in memory or increases in brain inflammation. These data raise the possibility that FO supplementation for purposes of cardiac and brain protection may need to occur earlier in the life span.

Original languageEnglish (US)
Pages (from-to)521-533
Number of pages13
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume66 A
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

Keywords

  • 3 fatty acids
  • Cardiac fibrosis
  • Fish oil
  • Hippocampus
  • Microglia
  • Omega

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Fingerprint

Dive into the research topics of 'Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats'. Together they form a unique fingerprint.

Cite this