Diet, lipids and colon cancer

Songhwa Choi, Ashley J. Snider

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

Dietary fat is digested and absorbed in the small intestine and can then be utilized as an energy source and/or as a reservoir for other bioactive lipid species. Excessive dietary fat has been implicated in the induction and/or aggravation of several diseases, including colorectal cancer (CRC). Diets with high fat content have been shown to exacerbate CRC through regulation of intestinal inflammation and proliferation, as well as alteration of bile acid pools, microbiota, and bioactive lipid species. This chapter will investigate the effects of dietary fat on CRC development and pathobiology, and possible mechanisms for specific lipid species in those processes.

Original languageEnglish (US)
Title of host publicationCellular Nutrient Utilization and Cancer
EditorsDavid C. Montrose, Lorenzo Galluzzi
PublisherElsevier Inc.
Pages105-144
Number of pages40
ISBN (Print)9780128184066
DOIs
StatePublished - 2019
Externally publishedYes

Publication series

NameInternational Review of Cell and Molecular Biology
Volume347
ISSN (Print)1937-6448

Keywords

  • Colitis-associated cancer
  • Colon cancer
  • Dietary lipid
  • Eicosanoid
  • Microbiota
  • Phospholipid
  • Polyunsaturated fatty acid
  • Saturated fatty acid
  • Sphingolipid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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