TY - JOUR
T1 - Diet and biomarkers of oxidative damage in women previously treated for breast cancer
AU - Thomson, Cynthia A.
AU - Giuliano, Anna R.
AU - Shaw, James W.
AU - Rock, Cheryl L.
AU - Ritenbaugh, Cheryl K.
AU - Hakim, Iman A.
AU - Hollenbach, Kathryn A.
AU - Alberts, David S.
AU - Pierce, John P.
N1 - Funding Information:
This study was supported in part by grants CA-23074 and CA-69375-02 from the National Cancer Institute. Additional funding was provided by a grant to Dr. Thomson from the Cancer Research and Prevention Foundation (Alexandria, VA). The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute. Special gratitude is extended to the women who partici- pated in this study. In addition, we would like to acknowledge the staff of the WHEL research program clinical sites in Arizona, Portland, and San Diego and at the Coordinating Center in San Diego for their support in subject enrollment and data collection, Genox Corporation for analytical support, and Jennifer Childs for assistance with the statistical analyses. Address correspondence to Cynthia A. Thomson, Cancer Prevention and Control, Arizona Cancer Center, Room 2964C, The University of Arizona, PO Box 245024, Tucson, AZ 85724–5024. Phone: (520) 626–9294. FAX: (520) 626–5350. E-mail: [email protected].
PY - 2005
Y1 - 2005
N2 - This study sought to evaluate the relationship between dietary intake of fat, poly unsaturated fat, saturated fat, arachidonic acid, and selected dietary antioxidants and levels of oxidative damage as measured by urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-epi-prostaglandin F2α (8-iso-PGF2α) in women previously treated for breast cancer. Two hundred two study subjects participating in the Women's Healthy Eating and Living (WHEL) study were included in this ancillary study. Dietary intakes and concentrations of urinary 8-OHdG and 8-iso-PGF2α were measured at baseline and 12 mo in the 179 women included in the analytical cohort. Study subjects demonstrated a significant reduction in dietary total, poly unsaturated, and saturated fat intake and a significant increase in vitamins E and C and β-carotene intake from baseline to 12 mo. Linear mixed-models analysis using baseline and Year 1 data indicated that vitamin E intake was inversely associated with both 8-OHdG and 8-iso-PGF2α. 8-Iso-PGF2α is increased with increased body mass index (BMI) and polyunsaturated fatty acid (PUFA) intake, indicating an increase in lipid peroxidation with greater BMI and higher PUFA intake. 8-OHdG was inversely related to age but positively related to arachidonic acid, indicating an increase in DNA damage with higher intake of arachidonic acid (meat). The results of this nested case-controlled study provide potential mechanisms by which a high fruit and vegetable, low-fat diet might reduce the recurrence rate of or early-stage breast cancer.
AB - This study sought to evaluate the relationship between dietary intake of fat, poly unsaturated fat, saturated fat, arachidonic acid, and selected dietary antioxidants and levels of oxidative damage as measured by urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-epi-prostaglandin F2α (8-iso-PGF2α) in women previously treated for breast cancer. Two hundred two study subjects participating in the Women's Healthy Eating and Living (WHEL) study were included in this ancillary study. Dietary intakes and concentrations of urinary 8-OHdG and 8-iso-PGF2α were measured at baseline and 12 mo in the 179 women included in the analytical cohort. Study subjects demonstrated a significant reduction in dietary total, poly unsaturated, and saturated fat intake and a significant increase in vitamins E and C and β-carotene intake from baseline to 12 mo. Linear mixed-models analysis using baseline and Year 1 data indicated that vitamin E intake was inversely associated with both 8-OHdG and 8-iso-PGF2α. 8-Iso-PGF2α is increased with increased body mass index (BMI) and polyunsaturated fatty acid (PUFA) intake, indicating an increase in lipid peroxidation with greater BMI and higher PUFA intake. 8-OHdG was inversely related to age but positively related to arachidonic acid, indicating an increase in DNA damage with higher intake of arachidonic acid (meat). The results of this nested case-controlled study provide potential mechanisms by which a high fruit and vegetable, low-fat diet might reduce the recurrence rate of or early-stage breast cancer.
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U2 - 10.1207/s15327914nc5102_4
DO - 10.1207/s15327914nc5102_4
M3 - Article
C2 - 15860436
AN - SCOPUS:19544364660
SN - 0163-5581
VL - 51
SP - 146
EP - 154
JO - Nutrition and cancer
JF - Nutrition and cancer
IS - 2
ER -