@article{e2d9c2416b004c22a51087c5cb96accc,
title = "Dieckmann Condensation of Ugi N-Acylamino Amide Product: Facile Access to Functionalized 2,2-Disubstituted Indolin-3-ones",
abstract = "Structurally unique 2,2-disubstituted indolin-3-ones with a quaternary carbon center have been constructed through a novel C-C bond formation at the C3 position of Ugi N-acylamino amide adducts employing an organic base-mediated Dieckmann condensation. This facile, flexible protocol can be fine-tuned to construct drug-like pyrazino[1,2-a]indole fragments with the same quaternary carbon center only through the variation of the acid part in Ugi input. This novel and expeditious methodology has a broad scope and can rapidly generate the drug-like indolin-3-one core.",
author = "Yong Li and Jia Xu and He, {Liu Jun} and Luo, {Ya Fei} and Meng, {Jiang Ping} and Tang, {Dian Yong} and Li, {Hong Yu} and Chen, {Zhong Zhu} and Xu, {Zhi Gang}",
note = "Funding Information: The authors would like to thank the Science and Technology Research Program of Chongqing Municipal Education Commission (KJQN202001338), the Chongqing Research Program of Basic Research and Frontier Technology (cstc2019jcyj-msxmX0012 and cstc2020jcyj-msxmX0733), and the Scientific Research Foundation of the Chongqing University of Arts and Sciences (2017RBX09 and P2019XY01). We would also like to thank Ms H. Z. Liu for obtaining the LC-MS, HRMS, and NMR data. Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",
year = "2022",
month = jan,
day = "7",
doi = "10.1021/acs.joc.1c02501",
language = "English (US)",
volume = "87",
pages = "823--834",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "1",
}