Dichotomous effects of latent CMV infection on the phenotype and functional properties of CD8+ T-cells and NK-cells

Austin B. Bigley, Guillaume Spielmann, Nadia Agha, Daniel P. O'Connor, Richard J. Simpson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

CMV markedly alters the phenotype and function of NK-cells and T-cells and has been linked to immunosenescence. We show here that subjects with effective CMV control (evidenced by low CMV IgG titers) have functional responses to CMV that are driven by either NKG2C+ NK-cells or CMV-specific T-cells (15 of 24 subjects), but not both. These data indicate that people with effective CMV control are either NK-cell or T-cell responders, and corroborates the idea that NK-cells have rheostat-like properties that regulate anti-viral T-cell responses. Whether or not lifelong CMV control through either NK-cell or T-cell responses have implications for immunosenescence remains to be determined.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalCellular Immunology
Volume300
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • Aging
  • CD27
  • CD28
  • CD57
  • Cytotoxicity
  • IE1
  • Immunosenescence
  • K562
  • NKCA
  • NKG2C
  • pp65
  • Viral load

ASJC Scopus subject areas

  • Immunology

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