Diazepam kinetics in acute alcohol withdrawal

Susan M. Pond; Michael Phillips; Neal L. Benowitz; Raymond E. Galinsky; Theodore G. Tong; Charles E. Becker

doi:10.1002/cpt1979256832

Diazepam kinetics in acute alcohol withdrawal

Susan M. Pond
, Michael Phillips
, Neal L. Benowitz
, Raymond E. Galinsky
, Theodore G. Tong
, Charles E. Becker

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We performed a within-subject comparison of the kinetics of diazepam given to 7 alcoholic subjects during acute alcohol withdrawal and again after detoxification. The initial rapid exponential decline of plasma diazepam concentrations (t 1 2α was more rapid during (0.21 ± 0.03 hr) than after withdrawal (0.44 ± 0.14 hr, p < 0.05). Terminal t 1 2 clearance, and volumes of distribution changed in individual patients, but mean values did not change. Protein binding was less in patients (93.4 ± 2.4 %) than in healthy controls (97.0 ± 1.0, p < 0.05). The effects of alcohol withdrawal on diazepam disposition do not explain the high doses of diazepam commonly required to treat the withdrawal.

Original language	English (US)
Pages (from-to)	832-836
Number of pages	5
Journal	Clinical Pharmacology and Therapeutics
Volume	25
Issue number	6
DOIs	https://doi.org/10.1002/cpt1979256832
State	Published - Jun 1979
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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title = "Diazepam kinetics in acute alcohol withdrawal",

abstract = "We performed a within-subject comparison of the kinetics of diazepam given to 7 alcoholic subjects during acute alcohol withdrawal and again after detoxification. The initial rapid exponential decline of plasma diazepam concentrations (t 1 2α was more rapid during (0.21 ± 0.03 hr) than after withdrawal (0.44 ± 0.14 hr, p < 0.05). Terminal t 1 2 clearance, and volumes of distribution changed in individual patients, but mean values did not change. Protein binding was less in patients (93.4 ± 2.4 \%) than in healthy controls (97.0 ± 1.0, p < 0.05). The effects of alcohol withdrawal on diazepam disposition do not explain the high doses of diazepam commonly required to treat the withdrawal.",

author = "Pond, \{Susan M.\} and Michael Phillips and Benowitz, \{Neal L.\} and Galinsky, \{Raymond E.\} and Tong, \{Theodore G.\} and Becker, \{Charles E.\}",

year = "1979",

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doi = "10.1002/cpt1979256832",

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TY - JOUR

T1 - Diazepam kinetics in acute alcohol withdrawal

AU - Pond, Susan M.

AU - Phillips, Michael

AU - Benowitz, Neal L.

AU - Galinsky, Raymond E.

AU - Tong, Theodore G.

AU - Becker, Charles E.

PY - 1979/6

Y1 - 1979/6

N2 - We performed a within-subject comparison of the kinetics of diazepam given to 7 alcoholic subjects during acute alcohol withdrawal and again after detoxification. The initial rapid exponential decline of plasma diazepam concentrations (t 1 2α was more rapid during (0.21 ± 0.03 hr) than after withdrawal (0.44 ± 0.14 hr, p < 0.05). Terminal t 1 2 clearance, and volumes of distribution changed in individual patients, but mean values did not change. Protein binding was less in patients (93.4 ± 2.4 %) than in healthy controls (97.0 ± 1.0, p < 0.05). The effects of alcohol withdrawal on diazepam disposition do not explain the high doses of diazepam commonly required to treat the withdrawal.

AB - We performed a within-subject comparison of the kinetics of diazepam given to 7 alcoholic subjects during acute alcohol withdrawal and again after detoxification. The initial rapid exponential decline of plasma diazepam concentrations (t 1 2α was more rapid during (0.21 ± 0.03 hr) than after withdrawal (0.44 ± 0.14 hr, p < 0.05). Terminal t 1 2 clearance, and volumes of distribution changed in individual patients, but mean values did not change. Protein binding was less in patients (93.4 ± 2.4 %) than in healthy controls (97.0 ± 1.0, p < 0.05). The effects of alcohol withdrawal on diazepam disposition do not explain the high doses of diazepam commonly required to treat the withdrawal.

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JO - Clinical Pharmacology and Therapeutics

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Diazepam kinetics in acute alcohol withdrawal

Abstract

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