Diastereospecific tandem Michael-like addition / electrophilic bromination: A one-pot tandem asymmetric synthesis of precursors of unusual amino acids

Guigen Li; Mark A. Jarosinski; Victor J. Hruby

doi:10.1016/S0040-4039(00)77625-8

Diastereospecific tandem Michael-like addition / electrophilic bromination: A one-pot tandem asymmetric synthesis of precursors of unusual amino acids

Guigen Li, Mark A. Jarosinski, Victor J. Hruby

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

A systematic series of key intermediates of unusual β-methyl-amino acids have been synthesized by using a modified Evans auxiliary in an asymmetric Michael-like reaction followed by direct bromination in a one-pot reaction.

Original language	English (US)
Pages (from-to)	2561-2564
Number of pages	4
Journal	Tetrahedron Letters
Volume	34
Issue number	16
DOIs	https://doi.org/10.1016/S0040-4039(00)77625-8
State	Published - Apr 16 1993

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)77625-8

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title = "Diastereospecific tandem Michael-like addition / electrophilic bromination: A one-pot tandem asymmetric synthesis of precursors of unusual amino acids",

abstract = "A systematic series of key intermediates of unusual β-methyl-amino acids have been synthesized by using a modified Evans auxiliary in an asymmetric Michael-like reaction followed by direct bromination in a one-pot reaction.",

author = "Guigen Li and Jarosinski, {Mark A.} and Hruby, {Victor J.}",

year = "1993",

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T2 - A one-pot tandem asymmetric synthesis of precursors of unusual amino acids

AU - Li, Guigen

AU - Jarosinski, Mark A.

AU - Hruby, Victor J.

PY - 1993/4/16

Y1 - 1993/4/16

N2 - A systematic series of key intermediates of unusual β-methyl-amino acids have been synthesized by using a modified Evans auxiliary in an asymmetric Michael-like reaction followed by direct bromination in a one-pot reaction.

AB - A systematic series of key intermediates of unusual β-methyl-amino acids have been synthesized by using a modified Evans auxiliary in an asymmetric Michael-like reaction followed by direct bromination in a one-pot reaction.

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U2 - 10.1016/S0040-4039(00)77625-8

DO - 10.1016/S0040-4039(00)77625-8

M3 - Article

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SN - 0040-4039

VL - 34

SP - 2561

EP - 2564

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 16

ER -

Diastereospecific tandem Michael-like addition / electrophilic bromination: A one-pot tandem asymmetric synthesis of precursors of unusual amino acids

Abstract

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