Abstract
A diastereo- and enantioselective conjugate addition reaction of γ-butenolide with chalcones has been developed. Notably, unmodified γ-butenolide was directly employed as a nucleophile in the Michael addition reactions. This process was catalyzed by a previously reported cyclohexane diamine thiourea under mild reaction conditions to afford enantioenriched synthetically and biologically important substituted furanones.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1303-1306 |
| Number of pages | 4 |
| Journal | Chemistry - An Asian Journal |
| Volume | 5 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2010 |
| Externally published | Yes |
Keywords
- Enones
- Lactones
- Michael addition organocatalysis
- Thioureas
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
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