Diastereo- and enantioselective organocatalytic direct conjugate addition of γ-Butenolide to chalcones

Yinan Zhang, Chenguang Yu, Yafei Ji, Wei Wang

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

A diastereo- and enantioselective conjugate addition reaction of γ-butenolide with chalcones has been developed. Notably, unmodified γ-butenolide was directly employed as a nucleophile in the Michael addition reactions. This process was catalyzed by a previously reported cyclohexane diamine thiourea under mild reaction conditions to afford enantioenriched synthetically and biologically important substituted furanones.

Original languageEnglish (US)
Pages (from-to)1303-1306
Number of pages4
JournalChemistry - An Asian Journal
Volume5
Issue number6
DOIs
StatePublished - Jun 1 2010
Externally publishedYes

Keywords

  • Enones
  • Lactones
  • Michael addition organocatalysis
  • Thioureas

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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