Diagnostic blood flow monitoring during therapeutic interventions using color Doppler optical coherence tomography

Siavash Yazdanfar; Manish D. Kulkarni; Richard C.K. Wong; Michael V. Sivak; Joseph Willis; Jennifer K. Barton; Ashley J. Welch; Joseph A. Izatt

doi:10.1117/12.306046

Diagnostic blood flow monitoring during therapeutic interventions using color Doppler optical coherence tomography

Siavash Yazdanfar, Manish D. Kulkarni, Richard C.K. Wong, Michael V. Sivak, Joseph Willis, Jennifer K. Barton, Ashley J. Welch, Joseph A. Izatt

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

A recently developed modality for blood flow measurement holds high promise in the management of bleeding ulcers. Color Doppler optical coherence tomography (CDOCT) uses low-coherence interferometry and digital signal processing to obtain precise localization of tissue microstructure simultaneous with bi-directional quantitation of blood flow. We discuss CDOCT as a diagnostic tool in the management of bleeding gastrointestinal lesions. Common treatments for bleeding ulcers include local injection of a vasoconstrictor, coagulation of blood via thermal contact or laser treatment, and necrosis of surrounding tissue with a sclerosant. We implemented these procedures in a rat dorsal skin flap model, and acquired CDOCT images before and after treatment. In these studies, CDOCT succeeded in identifying cessation of flow before it could be determined visually. Hence, we demonstrate the diagnostic capabilities of CDOCT in the regulation of bleeding in micron-scale vessels.

Original language	English (US)
Pages (from-to)	126-132
Number of pages	7
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	3251
DOIs	https://doi.org/10.1117/12.306046
State	Published - 1998
Externally published	Yes
Event	Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II - San Jose, CA, United States Duration: Jan 27 1998 → Jan 28 1998

Keywords

Bleeding peptic ulcers
Color Doppler optical coherence tomography (CDOCT)
Endoscopic treatments
High-risk stigmata

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.306046

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@article{31466fc974134108a0f410f736370310,

title = "Diagnostic blood flow monitoring during therapeutic interventions using color Doppler optical coherence tomography",

abstract = "A recently developed modality for blood flow measurement holds high promise in the management of bleeding ulcers. Color Doppler optical coherence tomography (CDOCT) uses low-coherence interferometry and digital signal processing to obtain precise localization of tissue microstructure simultaneous with bi-directional quantitation of blood flow. We discuss CDOCT as a diagnostic tool in the management of bleeding gastrointestinal lesions. Common treatments for bleeding ulcers include local injection of a vasoconstrictor, coagulation of blood via thermal contact or laser treatment, and necrosis of surrounding tissue with a sclerosant. We implemented these procedures in a rat dorsal skin flap model, and acquired CDOCT images before and after treatment. In these studies, CDOCT succeeded in identifying cessation of flow before it could be determined visually. Hence, we demonstrate the diagnostic capabilities of CDOCT in the regulation of bleeding in micron-scale vessels.",

keywords = "Bleeding peptic ulcers, Color Doppler optical coherence tomography (CDOCT), Endoscopic treatments, High-risk stigmata",

author = "Siavash Yazdanfar and Kulkarni, {Manish D.} and Wong, {Richard C.K.} and Sivak, {Michael V.} and Joseph Willis and Barton, {Jennifer K.} and Welch, {Ashley J.} and Izatt, {Joseph A.}",

year = "1998",

doi = "10.1117/12.306046",

language = "English (US)",

volume = "3251",

pages = "126--132",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

publisher = "SPIE",

note = "Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II ; Conference date: 27-01-1998 Through 28-01-1998",

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TY - JOUR

T1 - Diagnostic blood flow monitoring during therapeutic interventions using color Doppler optical coherence tomography

AU - Yazdanfar, Siavash

AU - Kulkarni, Manish D.

AU - Wong, Richard C.K.

AU - Sivak, Michael V.

AU - Willis, Joseph

AU - Barton, Jennifer K.

AU - Welch, Ashley J.

AU - Izatt, Joseph A.

PY - 1998

Y1 - 1998

N2 - A recently developed modality for blood flow measurement holds high promise in the management of bleeding ulcers. Color Doppler optical coherence tomography (CDOCT) uses low-coherence interferometry and digital signal processing to obtain precise localization of tissue microstructure simultaneous with bi-directional quantitation of blood flow. We discuss CDOCT as a diagnostic tool in the management of bleeding gastrointestinal lesions. Common treatments for bleeding ulcers include local injection of a vasoconstrictor, coagulation of blood via thermal contact or laser treatment, and necrosis of surrounding tissue with a sclerosant. We implemented these procedures in a rat dorsal skin flap model, and acquired CDOCT images before and after treatment. In these studies, CDOCT succeeded in identifying cessation of flow before it could be determined visually. Hence, we demonstrate the diagnostic capabilities of CDOCT in the regulation of bleeding in micron-scale vessels.

AB - A recently developed modality for blood flow measurement holds high promise in the management of bleeding ulcers. Color Doppler optical coherence tomography (CDOCT) uses low-coherence interferometry and digital signal processing to obtain precise localization of tissue microstructure simultaneous with bi-directional quantitation of blood flow. We discuss CDOCT as a diagnostic tool in the management of bleeding gastrointestinal lesions. Common treatments for bleeding ulcers include local injection of a vasoconstrictor, coagulation of blood via thermal contact or laser treatment, and necrosis of surrounding tissue with a sclerosant. We implemented these procedures in a rat dorsal skin flap model, and acquired CDOCT images before and after treatment. In these studies, CDOCT succeeded in identifying cessation of flow before it could be determined visually. Hence, we demonstrate the diagnostic capabilities of CDOCT in the regulation of bleeding in micron-scale vessels.

KW - Bleeding peptic ulcers

KW - Color Doppler optical coherence tomography (CDOCT)

KW - Endoscopic treatments

KW - High-risk stigmata

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DO - 10.1117/12.306046

M3 - Conference article

AN - SCOPUS:0032226208

SN - 0277-786X

VL - 3251

SP - 126

EP - 132

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II

Y2 - 27 January 1998 through 28 January 1998

ER -

Diagnostic blood flow monitoring during therapeutic interventions using color Doppler optical coherence tomography

Abstract

Keywords

ASJC Scopus subject areas

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