Diagnosis and management of precocious puberty

M. D. Wheeler; D. M. Styne

doi:10.1016/S0031-3955(16)37010-9

Diagnosis and management of precocious puberty

M. D. Wheeler, D. M. Styne

Pediatrics

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The onset of pubertal development before the age of 8 years in girls and 9 years in boys constitutes precocious puberty. Central precocious puberty results from premature activation of the hypothalamic-pituitary-gonadal axis, and peripheral precocious puberty results from extrapituitary gonadotropin secretion or secretion of sex steroids independent of pituitary gonadotropins. Long-acting GnRH agonists afford effective, selective, and reversible therapy of cental precocious puberty without significant toxicity. GnRH agonists are not effective in managing the premature sexual maturation associated with peripheral precocious puberty, but a number of other agents have been used with some success.

Original language	English (US)
Pages (from-to)	1255-1271
Number of pages	17
Journal	Pediatric Clinics of North America
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/S0031-3955(16)37010-9
State	Published - 1990

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0031-3955(16)37010-9

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abstract = "The onset of pubertal development before the age of 8 years in girls and 9 years in boys constitutes precocious puberty. Central precocious puberty results from premature activation of the hypothalamic-pituitary-gonadal axis, and peripheral precocious puberty results from extrapituitary gonadotropin secretion or secretion of sex steroids independent of pituitary gonadotropins. Long-acting GnRH agonists afford effective, selective, and reversible therapy of cental precocious puberty without significant toxicity. GnRH agonists are not effective in managing the premature sexual maturation associated with peripheral precocious puberty, but a number of other agents have been used with some success.",

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AU - Styne, D. M.

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N2 - The onset of pubertal development before the age of 8 years in girls and 9 years in boys constitutes precocious puberty. Central precocious puberty results from premature activation of the hypothalamic-pituitary-gonadal axis, and peripheral precocious puberty results from extrapituitary gonadotropin secretion or secretion of sex steroids independent of pituitary gonadotropins. Long-acting GnRH agonists afford effective, selective, and reversible therapy of cental precocious puberty without significant toxicity. GnRH agonists are not effective in managing the premature sexual maturation associated with peripheral precocious puberty, but a number of other agents have been used with some success.

AB - The onset of pubertal development before the age of 8 years in girls and 9 years in boys constitutes precocious puberty. Central precocious puberty results from premature activation of the hypothalamic-pituitary-gonadal axis, and peripheral precocious puberty results from extrapituitary gonadotropin secretion or secretion of sex steroids independent of pituitary gonadotropins. Long-acting GnRH agonists afford effective, selective, and reversible therapy of cental precocious puberty without significant toxicity. GnRH agonists are not effective in managing the premature sexual maturation associated with peripheral precocious puberty, but a number of other agents have been used with some success.

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Diagnosis and management of precocious puberty

Abstract

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