The onset of pubertal development before the age of 8 years in girls and 9 years in boys constitutes precocious puberty. Central precocious puberty results from premature activation of the hypothalamic-pituitary-gonadal axis, and peripheral precocious puberty results from extrapituitary gonadotropin secretion or secretion of sex steroids independent of pituitary gonadotropins. Long-acting GnRH agonists afford effective, selective, and reversible therapy of cental precocious puberty without significant toxicity. GnRH agonists are not effective in managing the premature sexual maturation associated with peripheral precocious puberty, but a number of other agents have been used with some success.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health