Diabetic foot ulcers: Part I. Pathophysiology and prevention

Afsaneh Alavi, R. Gary Sibbald, Dieter Mayer, Laurie Goodman, Mariam Botros, David G. Armstrong, Kevin Woo, Thomas Boeni, Elizabeth A. Ayello, Robert S. Kirsner

Research output: Contribution to journalReview articlepeer-review

189 Scopus citations


Diabetes mellitus is a serious, life-long condition that is the sixth leading cause of death in North America. Dermatologists frequently encounter patients with diabetes mellitus. Up to 25% of patients with diabetes mellitus will develop diabetic foot ulcers. Foot ulcer patients have an increased risk of amputation and increased mortality rate. The high-risk diabetic foot can be identified with a simplified screening, and subsequent foot ulcers can be prevented. Early recognition of the high-risk foot and timely treatment will save legs and improve patients' quality of life. Peripheral arterial disease, neuropathy, deformity, previous amputation, and infection are the main factors contributing to the development of diabetic foot ulcers. Early recognition of the high-risk foot is imperative to decrease the rates of mortality and morbidity. An interprofessional approach (ie, physicians, nurses, and foot care specialists) is often needed to support patients' needs.

Original languageEnglish (US)
Pages (from-to)1.e1-1.e18
JournalJournal of the American Academy of Dermatology
Issue number1
StatePublished - Jan 2014


  • diabetes
  • diabetic foot ulcer
  • neuropathy
  • wounds

ASJC Scopus subject areas

  • Dermatology


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