TY - JOUR
T1 - Deviation from linearity of drug solubility in ethanol/water mixtures
AU - Machatha, Stephen G.
AU - Bustamante, Pilar
AU - Yalkowsky, Samuel H.
N1 - Funding Information:
Pilar Bustamante acknowledges the financial support provided by project PM 99-0127, Ministerio de Ciencia y Tecnología, Spain and a grant from the NATO Scientific Committee.
PY - 2004/9/28
Y1 - 2004/9/28
N2 - A new empirical function that describes the deviation from linearity of solubility of a drug in an ethanol/water matrix is applied to the experimental data for 51 compounds. The proposed model is a more accurate predictor of the co-solvent solubility profile than a general third order polynomial with the same number of parameters. Both the root mean square error and average absolute error for the proposed model are significantly lower than those of existing models. The model also accurately predicts the fraction of co-solvent that gives maximum solubility (f max).
AB - A new empirical function that describes the deviation from linearity of solubility of a drug in an ethanol/water matrix is applied to the experimental data for 51 compounds. The proposed model is a more accurate predictor of the co-solvent solubility profile than a general third order polynomial with the same number of parameters. Both the root mean square error and average absolute error for the proposed model are significantly lower than those of existing models. The model also accurately predicts the fraction of co-solvent that gives maximum solubility (f max).
KW - Deviation from linearity
KW - Maximum solubility
KW - Solubility in an ethanol/water matrix
UR - http://www.scopus.com/inward/record.url?scp=4444303481&partnerID=8YFLogxK
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U2 - 10.1016/j.ijpharm.2004.06.020
DO - 10.1016/j.ijpharm.2004.06.020
M3 - Article
C2 - 15363504
AN - SCOPUS:4444303481
SN - 0378-5173
VL - 283
SP - 83
EP - 88
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -