Deviation from linearity of drug solubility in ethanol/water mixtures

Stephen G. Machatha, Pilar Bustamante, Samuel H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


A new empirical function that describes the deviation from linearity of solubility of a drug in an ethanol/water matrix is applied to the experimental data for 51 compounds. The proposed model is a more accurate predictor of the co-solvent solubility profile than a general third order polynomial with the same number of parameters. Both the root mean square error and average absolute error for the proposed model are significantly lower than those of existing models. The model also accurately predicts the fraction of co-solvent that gives maximum solubility (f max).

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
JournalInternational Journal of Pharmaceutics
Issue number1-2
StatePublished - Sep 28 2004


  • Deviation from linearity
  • Maximum solubility
  • Solubility in an ethanol/water matrix

ASJC Scopus subject areas

  • Pharmaceutical Science


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