Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes

Eric M. Small; Steven A. Vokes; Robert J. Garriock; Dongling Li; Paul A. Krieg

doi:10.1016/S0925-4773(00)00400-7

Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes

Eric M. Small
, Steven A. Vokes
, Robert J. Garriock
, Dongling Li
, Paul A. Krieg

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The homeodomain transcription factor Nkx2-l (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon.

Original language	English (US)
Pages (from-to)	259-262
Number of pages	4
Journal	Mechanisms of Development
Volume	96
Issue number	2
DOIs	https://doi.org/10.1016/S0925-4773(00)00400-7
State	Published - Sep 30 2000
Externally published	Yes

Keywords

Diencephalon
Esophagus
Forebrain
Homeobox gene
Lung
NK-2
Nkx2-1
Nkx2-4
Organogenesis
Thyroid

ASJC Scopus subject areas

Embryology
Developmental Biology

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10.1016/S0925-4773(00)00400-7

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title = "Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes",

abstract = "The homeodomain transcription factor Nkx2-l (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon.",

keywords = "Diencephalon, Esophagus, Forebrain, Homeobox gene, Lung, NK-2, Nkx2-1, Nkx2-4, Organogenesis, Thyroid",

author = "Small, \{Eric M.\} and Vokes, \{Steven A.\} and Garriock, \{Robert J.\} and Dongling Li and Krieg, \{Paul A.\}",

note = "Funding Information: We thank Thomas Hollemann for sharing information prior to publication, Mike King for providing the excellent stage 42 Xenopus laevis cDNA library and Karen Pilcher and Frank White for comments on the manuscript. This research was supported by NHLBI, NIH grants \#HL64763 and \#HL64764 to P.A.K.",

year = "2000",

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doi = "10.1016/S0925-4773(00)00400-7",

language = "English (US)",

volume = "96",

pages = "259--262",

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T1 - Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes

AU - Small, Eric M.

AU - Vokes, Steven A.

AU - Garriock, Robert J.

AU - Li, Dongling

AU - Krieg, Paul A.

N1 - Funding Information: We thank Thomas Hollemann for sharing information prior to publication, Mike King for providing the excellent stage 42 Xenopus laevis cDNA library and Karen Pilcher and Frank White for comments on the manuscript. This research was supported by NHLBI, NIH grants #HL64763 and #HL64764 to P.A.K.

PY - 2000/9/30

Y1 - 2000/9/30

N2 - The homeodomain transcription factor Nkx2-l (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon.

AB - The homeodomain transcription factor Nkx2-l (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon.

KW - Diencephalon

KW - Esophagus

KW - Forebrain

KW - Homeobox gene

KW - Lung

KW - NK-2

KW - Nkx2-1

KW - Nkx2-4

KW - Organogenesis

KW - Thyroid

UR - https://www.scopus.com/pages/publications/0034705991

UR - https://www.scopus.com/pages/publications/0034705991#tab=citedBy

U2 - 10.1016/S0925-4773(00)00400-7

DO - 10.1016/S0925-4773(00)00400-7

M3 - Article

C2 - 10960795

AN - SCOPUS:0034705991

SN - 0925-4773

VL - 96

SP - 259

EP - 262

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 2

ER -

Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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