Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes

Eric M. Small, Steven A. Vokes, Robert J. Garriock, Dongling Li, Paul A. Krieg

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


The homeodomain transcription factor Nkx2-l (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalMechanisms of Development
Issue number2
StatePublished - Sep 30 2000
Externally publishedYes


  • Diencephalon
  • Esophagus
  • Forebrain
  • Homeobox gene
  • Lung
  • NK-2
  • Nkx2-1
  • Nkx2-4
  • Organogenesis
  • Thyroid

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology


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