Developmental expression of glucokinase in rat hypothalamus

Vicki L. Sutherland; Matthew McReynolds; Linda S. Tompkins; Heddwen L. Brooks; Ronald M. Lynch

doi:10.1016/j.devbrainres.2004.11.001

Developmental expression of glucokinase in rat hypothalamus

Vicki L. Sutherland, Matthew McReynolds, Linda S. Tompkins, Heddwen L. Brooks, Ronald M. Lynch

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Neurons in the hypothalamus sense changes in glucose concentration. Glucokinase (GK), a key enzyme for pancreatic (β)-cell glucose sensing, was found in both the embryonic and adult hypothalamus. GK activity accounted for approximately 20% of total hexokinase (HK) activity in both embryonic and adult hypothalamus with no activity measured in cortical samples, indicating that glucose sensing in the hypothalamus initiates early in development and precedes the maturation of glucose signaling in liver.

Original language	English (US)
Pages (from-to)	255-258
Number of pages	4
Journal	Developmental Brain Research
Volume	154
Issue number	2
DOIs	https://doi.org/10.1016/j.devbrainres.2004.11.001
State	Published - Feb 8 2005

Keywords

Development
Glucokinase
Glucose sensing
RT-PCR

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/j.devbrainres.2004.11.001

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title = "Developmental expression of glucokinase in rat hypothalamus",

abstract = "Neurons in the hypothalamus sense changes in glucose concentration. Glucokinase (GK), a key enzyme for pancreatic (β)-cell glucose sensing, was found in both the embryonic and adult hypothalamus. GK activity accounted for approximately 20% of total hexokinase (HK) activity in both embryonic and adult hypothalamus with no activity measured in cortical samples, indicating that glucose sensing in the hypothalamus initiates early in development and precedes the maturation of glucose signaling in liver.",

keywords = "Development, Glucokinase, Glucose sensing, RT-PCR",

author = "Sutherland, {Vicki L.} and Matthew McReynolds and Tompkins, {Linda S.} and Brooks, {Heddwen L.} and Lynch, {Ronald M.}",

note = "Funding Information: This work was supported, in part, by a research grant from the American Diabetes Association. LST was supported by training grant HLBI-07249. We thank Alexandrina Barela and Molly Friedman for technical assistance.",

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T1 - Developmental expression of glucokinase in rat hypothalamus

AU - Sutherland, Vicki L.

AU - McReynolds, Matthew

AU - Tompkins, Linda S.

AU - Brooks, Heddwen L.

AU - Lynch, Ronald M.

N1 - Funding Information: This work was supported, in part, by a research grant from the American Diabetes Association. LST was supported by training grant HLBI-07249. We thank Alexandrina Barela and Molly Friedman for technical assistance.

PY - 2005/2/8

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N2 - Neurons in the hypothalamus sense changes in glucose concentration. Glucokinase (GK), a key enzyme for pancreatic (β)-cell glucose sensing, was found in both the embryonic and adult hypothalamus. GK activity accounted for approximately 20% of total hexokinase (HK) activity in both embryonic and adult hypothalamus with no activity measured in cortical samples, indicating that glucose sensing in the hypothalamus initiates early in development and precedes the maturation of glucose signaling in liver.

AB - Neurons in the hypothalamus sense changes in glucose concentration. Glucokinase (GK), a key enzyme for pancreatic (β)-cell glucose sensing, was found in both the embryonic and adult hypothalamus. GK activity accounted for approximately 20% of total hexokinase (HK) activity in both embryonic and adult hypothalamus with no activity measured in cortical samples, indicating that glucose sensing in the hypothalamus initiates early in development and precedes the maturation of glucose signaling in liver.

KW - Development

KW - Glucokinase

KW - Glucose sensing

KW - RT-PCR

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Developmental expression of glucokinase in rat hypothalamus

Abstract

Keywords

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