Developmental disorders of the lymphatic system

R. Greenlee, H. Hoyme, M. Witte, P. Crowe, C. Witte

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


Approximately 67% of human conceptuses die prenatally. Of these, a significant number involve a disorder of the lymphatic system. A small number of live-born children also exhibit congenital lymphatic malformations, including an estimated 60% of patients with Turner syndrome. These observations have prompted a search for the genetic and dysmorphologic basis and the different patterns of congenital lymphedema and associated anomalies. In this article, we attempt to summarize available pertinent information on congenital disorders of the lymphatic system and to propose a conceptual overview of lymphatic development.

Original languageEnglish (US)
Pages (from-to)156-168
Number of pages13
Issue number4
StatePublished - 1993

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology


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