Development of thromboresistant biomaterials. Immobilization of Hirudin onto polymers

Cecilia S.L. Ku; I. Bornstein; J. Breillatt; S. N. Ung-Chhun; R. Johnson; J. Lindon; S. Pokropinski; D. Rimer

Development of thromboresistant biomaterials. Immobilization of Hirudin onto polymers

Cecilia S.L. Ku, I. Bornstein, J. Breillatt, S. N. Ung-Chhun, R. Johnson, J. Lindon, S. Pokropinski, D. Rimer

Research output: Contribution to conference › Paper › peer-review

Abstract

The authors investigated the feasibility of coating polymers with hirudin to create new thromboresistant biomaterials. In the present study, various surfaces were coated with hirudin and subsequently examined for their effect(s) on the coagulation system and on platelet functions. Results obtained from this investigation suggest that hirudin can be immobilized onto the surface of various polymers for creating new thromboresistant biomaterials. For the maximum efficiency of hirudin-coated surfaces, it is necessary to select proper spacers and attachment sites on hirudin.

Original language	English (US)
Pages	44
Number of pages	1
State	Published - 1991
Externally published	Yes
Event	17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium - Scottsdale, AZ, USA Duration: May 1 1991 → May 5 1991

Other

Other	17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium
City	Scottsdale, AZ, USA
Period	5/1/91 → 5/5/91

ASJC Scopus subject areas

General Materials Science

Cite this

Ku, C. S. L., Bornstein, I., Breillatt, J., Ung-Chhun, S. N., Johnson, R., Lindon, J., Pokropinski, S., & Rimer, D. (1991). Development of thromboresistant biomaterials. Immobilization of Hirudin onto polymers. 44. Paper presented at 17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium, Scottsdale, AZ, USA.

Development of thromboresistant biomaterials. Immobilization of Hirudin onto polymers. / Ku, Cecilia S.L.; Bornstein, I.; Breillatt, J. et al.
1991. 44 Paper presented at 17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium, Scottsdale, AZ, USA.

Research output: Contribution to conference › Paper › peer-review

Ku, CSL, Bornstein, I, Breillatt, J, Ung-Chhun, SN, Johnson, R, Lindon, J, Pokropinski, S & Rimer, D 1991, 'Development of thromboresistant biomaterials. Immobilization of Hirudin onto polymers', Paper presented at 17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium, Scottsdale, AZ, USA, 5/1/91 - 5/5/91 pp. 44.

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AU - Ku, Cecilia S.L.

AU - Bornstein, I.

AU - Breillatt, J.

AU - Ung-Chhun, S. N.

AU - Johnson, R.

AU - Lindon, J.

AU - Pokropinski, S.

AU - Rimer, D.

PY - 1991

Y1 - 1991

N2 - The authors investigated the feasibility of coating polymers with hirudin to create new thromboresistant biomaterials. In the present study, various surfaces were coated with hirudin and subsequently examined for their effect(s) on the coagulation system and on platelet functions. Results obtained from this investigation suggest that hirudin can be immobilized onto the surface of various polymers for creating new thromboresistant biomaterials. For the maximum efficiency of hirudin-coated surfaces, it is necessary to select proper spacers and attachment sites on hirudin.

AB - The authors investigated the feasibility of coating polymers with hirudin to create new thromboresistant biomaterials. In the present study, various surfaces were coated with hirudin and subsequently examined for their effect(s) on the coagulation system and on platelet functions. Results obtained from this investigation suggest that hirudin can be immobilized onto the surface of various polymers for creating new thromboresistant biomaterials. For the maximum efficiency of hirudin-coated surfaces, it is necessary to select proper spacers and attachment sites on hirudin.

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M3 - Paper

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T2 - 17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium

Y2 - 1 May 1991 through 5 May 1991

ER -

Development of thromboresistant biomaterials. Immobilization of Hirudin onto polymers

Abstract

Other

ASJC Scopus subject areas

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