Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases

Robert B. Cameron, Craig C. Beeson, Rick G. Schnellmann

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Mitochondria have various roles in cellular metabolism and homeostasis. Because mitochondrial dysfunction is associated with many acute and chronic degenerative diseases, mitochondrial biogenesis (MB) is a therapeutic target for treating such diseases. Here, we review the role of mitochondrial dysfunction in acute and chronic degenerative diseases and the cellular signaling pathways by which MB is induced. We then review existing work describing the development and application of drugs that induce MB in vitro and in vivo. In particular, we discuss natural products and modulators of transcription factors, kinases, cyclic nucleotides, and G protein-coupled receptors.

Original languageEnglish (US)
Pages (from-to)10411-10434
Number of pages24
JournalJournal of Medicinal Chemistry
Volume59
Issue number23
DOIs
StatePublished - Dec 8 2016
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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