Development of the gonadotropin-releasing hormone system

Anne H. Duittoz; Paolo E. Forni; Paolo Giacobini; Matan Golan; Patrice Mollard; Ariel L. Negrón; Sally Radovick; Susan Wray

doi:10.1111/jne.13087

Development of the gonadotropin-releasing hormone system

Anne H. Duittoz
, Paolo E. Forni
, Paolo Giacobini
, Matan Golan
, Patrice Mollard
, Ariel L. Negrón
, Sally Radovick
, Susan Wray

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

This review summarizes the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.

Original language	English (US)
Article number	e13087
Journal	Journal of Neuroendocrinology
Volume	34
Issue number	5
DOIs	https://doi.org/10.1111/jne.13087
State	Published - May 2022
Externally published	Yes

Keywords

development
GnRH
guidance cues
migratory pathway
olfactory ensheathing cells
olfactory placode
synaptic and paracrine signals
terminal nerve
transcription factors

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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10.1111/jne.13087

Cite this

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title = "Development of the gonadotropin-releasing hormone system",

abstract = "This review summarizes the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.",

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AU - Duittoz, Anne H.

AU - Forni, Paolo E.

AU - Giacobini, Paolo

AU - Golan, Matan

AU - Mollard, Patrice

AU - Negrón, Ariel L.

AU - Radovick, Sally

AU - Wray, Susan

N1 - Publisher Copyright: © 2021 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.This article has been contributed to by US Government employees and their work is in the public domain in the USA.

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AB - This review summarizes the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.

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KW - guidance cues

KW - migratory pathway

KW - olfactory ensheathing cells

KW - olfactory placode

KW - synaptic and paracrine signals

KW - terminal nerve

KW - transcription factors

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ER -

Development of the gonadotropin-releasing hormone system

Abstract

Keywords

ASJC Scopus subject areas

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