Development of Delta Opioid Peptides as Nonaddicting Analgesics

Rao S. Rapaka, Frank Porreca

Research output: Contribution to journalReview articlepeer-review

109 Scopus citations


Although much effort has been devoted to opioid research since the identification of enkephalins, understanding of the physiological importance and mechanisms of action of endogenous opioids lags behind understanding of opiate alkaloids such as morphine. In recent years, several novel approaches have been refined with promise for the successful development of the long-awaited nonaddicting analgesics that act at the opioid delta receptor. The present communication reviews these efforts.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalPharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Issue number1
StatePublished - Jan 1991


  • delta opioid peptides
  • drug development
  • nonaddicting analgesics
  • peptide drugs

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)


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