TY - JOUR
T1 - Development of auditory function in the tammar wallaby Macropus eugenii
AU - Hill, Kenneth G.
AU - Cone-Wesson, Barbara
AU - Liu, Guang Bin
N1 - Funding Information:
We thank Ms Amanda Devlin and Mr Kevin Williams for maintenance of the laboratory animals, Dr Andrew James for support with computing and Dr Lauren Marrotte and Professor Richard Mark for valuable discussions. B.C.-W. gratefully acknowledges support from the Department of Otolaryngology, University of Southern California and from the Beth Mclaren Smallwood Foundation at the University of Melbourne.
PY - 1998/3
Y1 - 1998/3
N2 - Auditory brainstem responses (ABRs) were evoked in developing wallabies by click and tone burst stimuli delivered by bone conduction and air conduction, at progressive stages of post-natal (pouch) life. ABRs were recorded through the onset of auditory responses (95-110 days), the opening of the external ear canal (125-130 days) and the maturation of ABR thresholds and latencies to values corresponding to those in adults (> 180 days). ABRs were evoked in response to bone-conducted clicks some days prior to the age at which an acoustically evoked response was first observed (around 95 days of pouch life). ABRs could be evoked by bone-conducted and intense air- conducted stimuli prior to opening of the ear canal. A trend of decreasing threshold and latency with age was observed for both modes of stimulation. The morphology of the ABR became more complex, according to both increased age and increased stimulus intensity. The ABR waveforms indicated relatively greater mechanosensitivity to bone-conducted stimuli than to air-conducted stimuli, prior to opening of the ear canal. Following opening of the ear canal, thresholds to air-conducted clicks and tones were substantially reduced and decreased further over the next 10-20 days, while thresholds to bone-conducted clicks continued slowly to decrease. Thresholds to tone bursts in the centre frequency range (4-12 kHz) remained less than those for low (0.5-1.5 kHz) and higher (16 kHz) frequencies. Latencies of an identified peak in ABR waveforms characteristically decreased with age (at constant stimulus intensity) and with stimulus intensity (for a given age). ABR waveforms obtained at progressive ages, but judged to be at corresponding sensation levels, underwent maturational changes, independent of conductive aspects of the wallabies' hearing, for 2-3 weeks after opening of the ear canal.
AB - Auditory brainstem responses (ABRs) were evoked in developing wallabies by click and tone burst stimuli delivered by bone conduction and air conduction, at progressive stages of post-natal (pouch) life. ABRs were recorded through the onset of auditory responses (95-110 days), the opening of the external ear canal (125-130 days) and the maturation of ABR thresholds and latencies to values corresponding to those in adults (> 180 days). ABRs were evoked in response to bone-conducted clicks some days prior to the age at which an acoustically evoked response was first observed (around 95 days of pouch life). ABRs could be evoked by bone-conducted and intense air- conducted stimuli prior to opening of the ear canal. A trend of decreasing threshold and latency with age was observed for both modes of stimulation. The morphology of the ABR became more complex, according to both increased age and increased stimulus intensity. The ABR waveforms indicated relatively greater mechanosensitivity to bone-conducted stimuli than to air-conducted stimuli, prior to opening of the ear canal. Following opening of the ear canal, thresholds to air-conducted clicks and tones were substantially reduced and decreased further over the next 10-20 days, while thresholds to bone-conducted clicks continued slowly to decrease. Thresholds to tone bursts in the centre frequency range (4-12 kHz) remained less than those for low (0.5-1.5 kHz) and higher (16 kHz) frequencies. Latencies of an identified peak in ABR waveforms characteristically decreased with age (at constant stimulus intensity) and with stimulus intensity (for a given age). ABR waveforms obtained at progressive ages, but judged to be at corresponding sensation levels, underwent maturational changes, independent of conductive aspects of the wallabies' hearing, for 2-3 weeks after opening of the ear canal.
KW - Auditory brainstem response
KW - Auditory development
KW - Marsupial development
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U2 - 10.1016/S0378-5955(97)00211-6
DO - 10.1016/S0378-5955(97)00211-6
M3 - Article
C2 - 9557980
AN - SCOPUS:0031919119
SN - 0378-5955
VL - 117
SP - 97
EP - 106
JO - Hearing Research
JF - Hearing Research
IS - 1-2
ER -