Development of an implantable artificial lung: Challenges and progress

Joseph B. Zwischenberger, Carryn M. Anderson, Keith E. Cook, Scott D. Lick, Lyle F. Mockros, Robert H. Bartlett

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Unlike dialysis, which functions as a bridge to renal transplantation, or a ventricular assist device, which serves as a bridge to cardiac transplantation, no suitable bridge to lung transplantation exists. Our goal is to design and build an ambulatory artificial lung that can be perfused entirely by the right ventricle and completely support the metabolic O2 and CO2 requirements of an adult. Such a device could realize a substantial clinical impact as a bridge to lung transplantation, as a support device immediately post-lung transplant, and as a rescue and/or supplement to mechanical ventilation during the treatment of severe respiratory failure. Research on the artificial lung has focused on the design, mode of attachment to the pulmonary circulation, and intracorporeal versus paracorporeal placement of the device.

Original languageEnglish (US)
Pages (from-to)316-320
Number of pages5
JournalASAIO Journal
Issue number4
StatePublished - 2001

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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