Development of a fiber-optic confocal microendoscope for clinical endoscopy

Andrew R. Rouse, Angelique Kano, Arthur F. Gmitro

Research output: Contribution to journalConference articlepeer-review

8 Scopus citations


A confocal microendoscope has been developed to examine cellular pathology during optical biopsy. The system employs a flexible fiber optic catheter coupled to a slit-scan confocal microscope to image tissue at remote locations in the body. The catheter of the confocal microendoscope consists of a fiber-optic imaging bundle, a miniature objective, and a miniature focusing mechanism. The system has a lateral resolution of 1.8μm and an axial resolution of 25μm. The confocal microendoscope can operate in a grayscale or multi-spectral imaging mode. Extensive work has been done to design a new miniature objective and focusing mechanism that will allow the catheter to be routed through the therapeutic channel of a clinical endoscope. We present the design for a miniature F/1 achromatic objective with nearly diffraction limited performance. The objective will be coupled to a pneumatic focusing mechanism to provide focus control to 200μm below the surface of the tissue. The new catheter has an overall diameter of 3mm with a rigid tip of only 20mm in length.

Original languageEnglish (US)
Pages (from-to)244-253
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2002
EventOptical Biopsy IV - San Jose, CA, United States
Duration: Jan 21 2002Jan 23 2002

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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