Abstract
A confocal microendoscope has been developed to examine cellular pathology during optical biopsy. The system employs a flexible fiber optic catheter coupled to a slit-scan confocal microscope to image tissue at remote locations in the body. The catheter of the confocal microendoscope consists of a fiber-optic imaging bundle, a miniature objective, and a miniature focusing mechanism. The system has a lateral resolution of 1.8μm and an axial resolution of 25μm. The confocal microendoscope can operate in a grayscale or multi-spectral imaging mode. Extensive work has been done to design a new miniature objective and focusing mechanism that will allow the catheter to be routed through the therapeutic channel of a clinical endoscope. We present the design for a miniature F/1 achromatic objective with nearly diffraction limited performance. The objective will be coupled to a pneumatic focusing mechanism to provide focus control to 200μm below the surface of the tissue. The new catheter has an overall diameter of 3mm with a rigid tip of only 20mm in length.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 244-253 |
| Number of pages | 10 |
| Journal | Proceedings of SPIE - The International Society for Optical Engineering |
| Volume | 4613 |
| DOIs | |
| State | Published - 2002 |
| Event | Optical Biopsy IV - San Jose, CA, United States Duration: Jan 21 2002 → Jan 23 2002 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering