Development of a contingency recruitment plan for a phase III chemoprevention trial of cervical dysplasia.

L. J. Loescher, V. E. Graham, M. Aickin, F. L. Meyskens, E. A. Surwit

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Development of contingency recruitment plans in cancer chemoprevention research is as important as formulation of the initial plan. We found that requesting recruitment information from our initial CTCD subjects provided a framework for our contingency plan. The revised recruitment plan consisted of: 1) calling and sending letters to community gynecologists in private practice or affiliated with HMO's to explain the study and ask for referrals; 2) continued personal contact by the principal investigator with referring physicians; 3) sending thank you and follow-up letters to every physician who referred patients to the study; 4) soliciting Papanicolaou smear reports from HMO's if physicians of women with abnormal Papanicolaou smears gave permission to pathologists to release this information; 5) utilizing free media such as feature articles on the CTCD in local papers, public service announcements, and television "spots;" 6) continued use of brochures and posters printed for the initial recruitment effort; and 7) continued presentations to local professional physician and nurse groups about the study. Our contingency plan to date has provided us with 100% of our projected accrual. Thus, our recruitment methods have proved to be effective in accruing subjects for this cancer chemoprevention trial.

Original languageEnglish (US)
Pages (from-to)151-163
Number of pages13
JournalProgress in clinical and biological research
StatePublished - 1990

ASJC Scopus subject areas

  • Medicine(all)


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