Development and use of a confocal microendoscope for in vivo histopathologic diagnosis

A. F. Gmitro; A. R. Rouse

doi:10.1117/12.427944

Development and use of a confocal microendoscope for in vivo histopathologic diagnosis

A. F. Gmitro, A. R. Rouse

Research output: Contribution to journal › Conference article › peer-review

2 Scopus citations

Abstract

A confocal microendoscope for in vivo imaging at the cellular level has been developed. The system consists of a slit-scanning confocal microscope coupled to a fiber optic imaging bundle with a miniature objective lens and focusing mechanism at the distal tip of the catheter. The system is used primarily for imaging tissue fluorescence - either autofluorescence or fluorescence from an exogenous compound. The microendoscope has a lateral resolution of 2 μm allowing visualization of structures at the cellular level, and because it is confocal, it can image at selected depths below the tissue surface. Excellent in vivo imaging results have been obtained in animal models and encouraging ex vivo results have been achieved with human tissue.

Original language	English (US)
Pages (from-to)	41-48
Number of pages	8
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4254
DOIs	https://doi.org/10.1117/12.427944
State	Published - 2001
Event	Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III - San Jose, CA, United States Duration: Jan 21 2001 → Jan 22 2001

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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title = "Development and use of a confocal microendoscope for in vivo histopathologic diagnosis",

abstract = "A confocal microendoscope for in vivo imaging at the cellular level has been developed. The system consists of a slit-scanning confocal microscope coupled to a fiber optic imaging bundle with a miniature objective lens and focusing mechanism at the distal tip of the catheter. The system is used primarily for imaging tissue fluorescence - either autofluorescence or fluorescence from an exogenous compound. The microendoscope has a lateral resolution of 2 μm allowing visualization of structures at the cellular level, and because it is confocal, it can image at selected depths below the tissue surface. Excellent in vivo imaging results have been obtained in animal models and encouraging ex vivo results have been achieved with human tissue.",

author = "Gmitro, {A. F.} and Rouse, {A. R.}",

year = "2001",

doi = "10.1117/12.427944",

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note = "Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III ; Conference date: 21-01-2001 Through 22-01-2001",

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T1 - Development and use of a confocal microendoscope for in vivo histopathologic diagnosis

AU - Gmitro, A. F.

AU - Rouse, A. R.

PY - 2001

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N2 - A confocal microendoscope for in vivo imaging at the cellular level has been developed. The system consists of a slit-scanning confocal microscope coupled to a fiber optic imaging bundle with a miniature objective lens and focusing mechanism at the distal tip of the catheter. The system is used primarily for imaging tissue fluorescence - either autofluorescence or fluorescence from an exogenous compound. The microendoscope has a lateral resolution of 2 μm allowing visualization of structures at the cellular level, and because it is confocal, it can image at selected depths below the tissue surface. Excellent in vivo imaging results have been obtained in animal models and encouraging ex vivo results have been achieved with human tissue.

AB - A confocal microendoscope for in vivo imaging at the cellular level has been developed. The system consists of a slit-scanning confocal microscope coupled to a fiber optic imaging bundle with a miniature objective lens and focusing mechanism at the distal tip of the catheter. The system is used primarily for imaging tissue fluorescence - either autofluorescence or fluorescence from an exogenous compound. The microendoscope has a lateral resolution of 2 μm allowing visualization of structures at the cellular level, and because it is confocal, it can image at selected depths below the tissue surface. Excellent in vivo imaging results have been obtained in animal models and encouraging ex vivo results have been achieved with human tissue.

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DO - 10.1117/12.427944

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VL - 4254

SP - 41

EP - 48

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III

Y2 - 21 January 2001 through 22 January 2001

ER -

Development and use of a confocal microendoscope for in vivo histopathologic diagnosis

Abstract

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