Development and testing of a single frequency terahertz imaging system for breast cancer detection

Benjamin St Peter; Sigfrid Yngvesson; Paul Siqueira; Patrick Kelly; Ashraf Khan; Stephen Glick; Andrew Karellas

doi:10.1109/TTHZ.2013.2241429

Development and testing of a single frequency terahertz imaging system for breast cancer detection

Benjamin St Peter, Sigfrid Yngvesson, Paul Siqueira, Patrick Kelly, Ashraf Khan, Stephen Glick, Andrew Karellas

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The ability to discern malignant frombenign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of 73% was found for five out of six samples using Receiver Operating Characteristic (ROC) analysis. The system design and characterization is discussed in detail. The initial results are encouraging but further development of the technology and clinical evaluation is needed to evaluate its feasibility in the clinical environment.

Original language	English (US)
Article number	6468149
Pages (from-to)	374-386
Number of pages	13
Journal	IEEE Transactions on Terahertz Science and Technology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1109/TTHZ.2013.2241429
State	Published - Jul 2013
Externally published	Yes

Keywords

Breast cancer
Medical imaging
Reflectivity
Refractive index
Single frequency THz imaging (SFTI)
THz

ASJC Scopus subject areas

Radiation
Electrical and Electronic Engineering

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10.1109/TTHZ.2013.2241429

Cite this

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abstract = "The ability to discern malignant frombenign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of 73% was found for five out of six samples using Receiver Operating Characteristic (ROC) analysis. The system design and characterization is discussed in detail. The initial results are encouraging but further development of the technology and clinical evaluation is needed to evaluate its feasibility in the clinical environment.",

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AU - Yngvesson, Sigfrid

AU - Siqueira, Paul

AU - Kelly, Patrick

AU - Khan, Ashraf

AU - Glick, Stephen

AU - Karellas, Andrew

PY - 2013/7

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AB - The ability to discern malignant frombenign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of 73% was found for five out of six samples using Receiver Operating Characteristic (ROC) analysis. The system design and characterization is discussed in detail. The initial results are encouraging but further development of the technology and clinical evaluation is needed to evaluate its feasibility in the clinical environment.

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KW - Reflectivity

KW - Refractive index

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Development and testing of a single frequency terahertz imaging system for breast cancer detection

Abstract

Keywords

ASJC Scopus subject areas

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