Developing Cyclic Opioid Analogues: Fluorescently Labeled Bioconjugates of Biphalin

Azzurra Stefanucci, Marilisa Pia Dimmito, Gabriela Molnar, John M. Streicher, Ettore Novellino, Gokhan Zengin, Adriano Mollica

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The development of bioconjugates is of pivotal importance in medicinal chemistry due to their potential applications as therapeutic agents to improve the targeting of specific diseases, decrease toxicity, or control drug release. In this work we achieved the synthesis and characterization of three novel opioid peptides fluorescently labeled, analogues of cyclic biphalin derivatives, namely 1D, 1C, and 2C. Among them, compound 1D, containing a dansyl-maleimide motif, exhibited an excellent binding affinity and functional potency for the δ-opioid receptor (DOR). 1D also demonstrated a strong fluorescence emission spectrum ranging from 300 to 700 nm. These features could be highly desirable for medical and biological applications needed for targeting the DOR, including in vivo imaging, and as a lead for the design of fluorescent probes.

Original languageEnglish (US)
Pages (from-to)720-726
Number of pages7
JournalACS Medicinal Chemistry Letters
Volume11
Issue number5
DOIs
StatePublished - May 14 2020
Externally publishedYes

Keywords

  • bioconjugates
  • Biphalin
  • fluorescent probes
  • GPCRs
  • opioids

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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