Determination of phosphate functional group acid dissociation constants of clindamycin 2-phosphate using 31P Fourier transform NMR spectrometry

James E. Kipp; Walter J. Smith; Paul B. Myrdal

doi:10.1016/0378-5173(91)90240-O

Determination of phosphate functional group acid dissociation constants of clindamycin 2-phosphate using ³¹P Fourier transform NMR spectrometry

James E. Kipp
, Walter J. Smith
, Paul B. Myrdal

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

³¹P-NMR spectrometric titration was used to determine the apparent first and second acid dissociation constants of the phosphate functional group in clindamycin 2-phosphate at 21°C. Using a standard rapid exchange model, values of 0.964 and 6.06 were determined.

Original language	English (US)
Pages (from-to)	215-220
Number of pages	6
Journal	International Journal of Pharmaceutics
Volume	74
Issue number	2-3
DOIs	https://doi.org/10.1016/0378-5173(91)90240-O
State	Published - Aug 16 1991
Externally published	Yes

Keywords

Acid dissociation
Clindamycin phosphate
NMR
P-NMR
pH dependence

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1016/0378-5173(91)90240-O

Cite this

@article{0042cea0b8624c7f94c0e53cf647db4b,

title = "Determination of phosphate functional group acid dissociation constants of clindamycin 2-phosphate using 31P Fourier transform NMR spectrometry",

abstract = "31P-NMR spectrometric titration was used to determine the apparent first and second acid dissociation constants of the phosphate functional group in clindamycin 2-phosphate at 21°C. Using a standard rapid exchange model, values of 0.964 and 6.06 were determined.",

keywords = "Acid dissociation, Clindamycin phosphate, NMR, P-NMR, pH dependence",

author = "Kipp, \{James E.\} and Smith, \{Walter J.\} and Myrdal, \{Paul B.\}",

year = "1991",

month = aug,

day = "16",

doi = "10.1016/0378-5173(91)90240-O",

language = "English (US)",

volume = "74",

pages = "215--220",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier B.V.",

number = "2-3",

}

TY - JOUR

T1 - Determination of phosphate functional group acid dissociation constants of clindamycin 2-phosphate using 31P Fourier transform NMR spectrometry

AU - Kipp, James E.

AU - Smith, Walter J.

AU - Myrdal, Paul B.

PY - 1991/8/16

Y1 - 1991/8/16

N2 - 31P-NMR spectrometric titration was used to determine the apparent first and second acid dissociation constants of the phosphate functional group in clindamycin 2-phosphate at 21°C. Using a standard rapid exchange model, values of 0.964 and 6.06 were determined.

AB - 31P-NMR spectrometric titration was used to determine the apparent first and second acid dissociation constants of the phosphate functional group in clindamycin 2-phosphate at 21°C. Using a standard rapid exchange model, values of 0.964 and 6.06 were determined.

KW - Acid dissociation

KW - Clindamycin phosphate

KW - NMR

KW - P-NMR

KW - pH dependence

UR - https://www.scopus.com/pages/publications/0025744174

UR - https://www.scopus.com/pages/publications/0025744174#tab=citedBy

U2 - 10.1016/0378-5173(91)90240-O

DO - 10.1016/0378-5173(91)90240-O

M3 - Article

AN - SCOPUS:0025744174

SN - 0378-5173

VL - 74

SP - 215

EP - 220

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 2-3

ER -