Abstract
The pharmacokinetics of 2,3-dimercaptopropane-1-sulfonate (DMPS), an effective chelating agent for mercury, were determined in five healthy adults after i.v. administration of 3.0 mg/kg of DMPS. DMPS is rapidly transformed to disulfide forms; 15 min after administration, only 12% of the total DMPS detected in blood was present as the parent drug. DMPS and its metabolites were eliminated primarily by the kidneys. By 96 hr after administration, 12% of the total DMPS found in the urine was excreted as the parent drug (10% of the administered dose) and 88% was excreted as disulfide metabolites (74% of the administered dose). The disposition of parent drug was described by a biexponential equation with an elimination half-life of 1.8 hr. By contrast, the elimination half-life of total DMPS was 20 hr. The oral bioavailability of the parent drug was found in a separate study to be 39%. Mercury excretion in healthy volunteers correlated well with the urinary excretion of both the parent drug (n = .94) and the disulfide metabolites (r2 = .96).
Original language | English (US) |
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Pages (from-to) | 662-668 |
Number of pages | 7 |
Journal | Journal of Pharmacology and Experimental Therapeutics |
Volume | 268 |
Issue number | 2 |
State | Published - 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology