Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results

Lindsey Egan; Patricia A. Connolly; Deanna Fuller; Thomas E. Davis; John Witt; Kenneth S. Knox; Chadi A. Hage; L. Joseph Wheat

doi:10.1128/CVI.00493-07

Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results

Lindsey Egan, Patricia A. Connolly, Deanna Fuller, Thomas E. Davis, John Witt, Kenneth S. Knox, Chadi A. Hage, L. Joseph Wheat

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Patients with histoplasmosis may test falsely negative for Histoplasma capsulatum antigenuria. In some cases antigen is present at levels below the assay's detection limit, and ultrafiltration could improve sensitivity. Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity.

Original language	English (US)
Pages (from-to)	726-728
Number of pages	3
Journal	Clinical and Vaccine Immunology
Volume	15
Issue number	4
DOIs	https://doi.org/10.1128/CVI.00493-07
State	Published - Apr 2008
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

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10.1128/CVI.00493-07

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abstract = "Patients with histoplasmosis may test falsely negative for Histoplasma capsulatum antigenuria. In some cases antigen is present at levels below the assay's detection limit, and ultrafiltration could improve sensitivity. Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity.",

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AU - Egan, Lindsey

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AU - Fuller, Deanna

AU - Davis, Thomas E.

AU - Witt, John

AU - Knox, Kenneth S.

AU - Hage, Chadi A.

AU - Wheat, L. Joseph

PY - 2008/4

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AB - Patients with histoplasmosis may test falsely negative for Histoplasma capsulatum antigenuria. In some cases antigen is present at levels below the assay's detection limit, and ultrafiltration could improve sensitivity. Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity.

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Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results

Abstract

ASJC Scopus subject areas

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