Detection of DT-diaphorase Enzyme with a ParaCEST MRI Contrast Agent

Iman Daryaei; Kyle M. Jones; Mark D. Pagel

doi:10.1002/chem.201700721

Detection of DT-diaphorase Enzyme with a ParaCEST MRI Contrast Agent

Iman Daryaei, Kyle M. Jones, Mark D. Pagel

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A responsive magnetic resonance (MRI) contrast agent has been developed that can detect the enzyme activity of DT-diaphorase. The agent produced different chemical exchange saturation transfer (CEST) MRI signals before and after incubation with the enzyme, NADH, and GSH at different pH values whereas it showed good stability in a reducing environment without enzyme.

Original language	English (US)
Pages (from-to)	6514-6517
Number of pages	4
Journal	Chemistry - A European Journal
Volume	23
Issue number	27
DOIs	https://doi.org/10.1002/chem.201700721
State	Published - May 11 2017

Keywords

CEST MRI
NQO1
dt-diaphorase
molecular imaging
trimethyl lock

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1002/chem.201700721

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abstract = "A responsive magnetic resonance (MRI) contrast agent has been developed that can detect the enzyme activity of DT-diaphorase. The agent produced different chemical exchange saturation transfer (CEST) MRI signals before and after incubation with the enzyme, NADH, and GSH at different pH values whereas it showed good stability in a reducing environment without enzyme.",

keywords = "CEST MRI, NQO1, dt-diaphorase, molecular imaging, trimethyl lock",

author = "Iman Daryaei and Jones, {Kyle M.} and Pagel, {Mark D.}",

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AB - A responsive magnetic resonance (MRI) contrast agent has been developed that can detect the enzyme activity of DT-diaphorase. The agent produced different chemical exchange saturation transfer (CEST) MRI signals before and after incubation with the enzyme, NADH, and GSH at different pH values whereas it showed good stability in a reducing environment without enzyme.

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KW - dt-diaphorase

KW - molecular imaging

KW - trimethyl lock

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Detection of DT-diaphorase Enzyme with a ParaCEST MRI Contrast Agent

Abstract

Keywords

ASJC Scopus subject areas

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