Detection of amphotericin B-resistant Candida isolates in a broth-based system

J. H. Rex; C. R. Cooper; W. G. Merz; J. N. Galgiani; E. J. Anaissie

doi:10.1128/AAC.39.4.906

Detection of amphotericin B-resistant Candida isolates in a broth-based system

J. H. Rex, C. R. Cooper, W. G. Merz, J. N. Galgiani, E. J. Anaissie

Research output: Contribution to journal › Article › peer-review

186 Scopus citations

Abstract

Because of the limited ability of the National Committee for Clinical Laboratory Standards proposed M27P methodology to detect resistance to amphotericin B by Candida isolates, we sought to identify alternative media and pH conditions that could reliably identify resistant isolates. Antibiotic Medium 3 broth (also known as Penassay broth) buffered to pH 5 or pH 7 produced superior results and readily identified a series of resistant isolates.

Original language	English (US)
Pages (from-to)	906-909
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	39
Issue number	4
DOIs	https://doi.org/10.1128/AAC.39.4.906
State	Published - 1995

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Because of the limited ability of the National Committee for Clinical Laboratory Standards proposed M27P methodology to detect resistance to amphotericin B by Candida isolates, we sought to identify alternative media and pH conditions that could reliably identify resistant isolates. Antibiotic Medium 3 broth (also known as Penassay broth) buffered to pH 5 or pH 7 produced superior results and readily identified a series of resistant isolates.",

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AU - Anaissie, E. J.

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AB - Because of the limited ability of the National Committee for Clinical Laboratory Standards proposed M27P methodology to detect resistance to amphotericin B by Candida isolates, we sought to identify alternative media and pH conditions that could reliably identify resistant isolates. Antibiotic Medium 3 broth (also known as Penassay broth) buffered to pH 5 or pH 7 produced superior results and readily identified a series of resistant isolates.

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Detection of amphotericin B-resistant Candida isolates in a broth-based system

Abstract

ASJC Scopus subject areas

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