Detection of amphotericin B-resistant Candida isolates in a broth-based system

J. H. Rex, C. R. Cooper, W. G. Merz, J. N. Galgiani, E. J. Anaissie

Research output: Contribution to journalArticlepeer-review

182 Scopus citations


Because of the limited ability of the National Committee for Clinical Laboratory Standards proposed M27P methodology to detect resistance to amphotericin B by Candida isolates, we sought to identify alternative media and pH conditions that could reliably identify resistant isolates. Antibiotic Medium 3 broth (also known as Penassay broth) buffered to pH 5 or pH 7 produced superior results and readily identified a series of resistant isolates.

Original languageEnglish (US)
Pages (from-to)906-909
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Issue number4
StatePublished - 1995

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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