Detection of abnormalities in biological tissue using optical coherence tomography

K. Cheong, E. Clarkson, J. P. Rolland

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We studied the performance of an OCT imaging modality on the task of detecting an abnormality in biological tissue. Optical propagation in biological samples is dominated by scattering due to fluctuations in refractive index. We used the first order multiple scattering approximation to describe the scattered field from the tissue. The biological tissue was described by it permittivity field and the corresponding scattering potential. The normal state of the tissue (the background) was modeled as a spatial Poisson field of randomly distributed scattering centers, and the abnormality (the target) as a region with a higher concentration of scattering centers embedded in the background. The target detectability was then calculated using a quadratic observer. We considered the effect of fluctuations from the broadband source, the shot noise fluctuation of the imaging system, and the scattering noise due to refractive index fluctuation in the biological tissue. We also studied the detectability of an embedded abnormality in biological tissue with respect to to size of th abnormality.

Original languageEnglish (US)
Title of host publicationDesign and Quality for Biomedical Technologies
StatePublished - 2008
EventDesign and Quality for Biomedical Technologies - San Jose, CA, United States
Duration: Jan 21 2008Jan 21 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherDesign and Quality for Biomedical Technologies
Country/TerritoryUnited States
CitySan Jose, CA


  • Optical Coherence Tomography
  • Scattering
  • Statistical decision theory

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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