Detecting molecular recognition with adaptive interferometry: The adaptive-optical BioCD

David D. Nolte, Leilei Peng

Research output: Contribution to journalConference articlepeer-review


We have developed a high-speed interferometric optical assay called the BioCD. It is a spinning disk on which antibody molecules are printed that test for specific proteins in biological samples. The class of the BioCD that I will describe here uses adaptive beam combining in a photorefractive quantum well device to establish interferometric phase quadrature between the signal and reference beams. The interferometer is linearly sensitive to small numbers of captured biological molecules and adaptively compensates for mechanical vibrations and wobble in the optical disk.

Original languageEnglish (US)
Pages (from-to)650-654
Number of pages5
JournalOSA Trends in Optics and Photonics Series
StatePublished - 2005
Event10th International Conference on Photorefractive, Effects, Materials, and Devices - Hainan, China
Duration: Jul 19 2005Jul 23 2005

ASJC Scopus subject areas

  • General Engineering


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