Detecting enzyme activities with exogenous MRI contrast agents

Dina V. Hingorani; Byunghee Yoo; Adam S. Bernstein; Mark D. Pagel

doi:10.1002/chem.201402474

Detecting enzyme activities with exogenous MRI contrast agents

Dina V. Hingorani, Byunghee Yoo, Adam S. Bernstein, Mark D. Pagel

Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

This review focuses on exogenous magnetic resonance imaging (MRI) contrast agents that are responsive to enzyme activity. Enzymes can catalyze a change in water access, rotational tumbling time, the proximity of a ¹⁹F- labeled ligand, the aggregation state, the proton chemical-exchange rate between the agent and water, or the chemical shift of ¹⁹F, ³¹P, ¹³C or a labile ¹H of an agent, all of which can be used to detect enzyme activity. The variety of agents attests to the creativity in developing enzyme-responsive MRI contrast agents.

Original language	English (US)
Pages (from-to)	9840-9850
Number of pages	11
Journal	Chemistry - A European Journal
Volume	20
Issue number	32
DOIs	https://doi.org/10.1002/chem.201402474
State	Published - Aug 4 2014

Keywords

CEST MRI
MR spectroscopy
enzymes
imaging agents
relaxation-based MRI

ASJC Scopus subject areas

General Chemistry
Catalysis
Organic Chemistry

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10.1002/chem.201402474

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title = "Detecting enzyme activities with exogenous MRI contrast agents",

abstract = "This review focuses on exogenous magnetic resonance imaging (MRI) contrast agents that are responsive to enzyme activity. Enzymes can catalyze a change in water access, rotational tumbling time, the proximity of a 19F- labeled ligand, the aggregation state, the proton chemical-exchange rate between the agent and water, or the chemical shift of 19F, 31P, 13C or a labile 1H of an agent, all of which can be used to detect enzyme activity. The variety of agents attests to the creativity in developing enzyme-responsive MRI contrast agents.",

keywords = "CEST MRI, MR spectroscopy, enzymes, imaging agents, relaxation-based MRI",

author = "Hingorani, {Dina V.} and Byunghee Yoo and Bernstein, {Adam S.} and Pagel, {Mark D.}",

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AU - Hingorani, Dina V.

AU - Yoo, Byunghee

AU - Bernstein, Adam S.

AU - Pagel, Mark D.

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N2 - This review focuses on exogenous magnetic resonance imaging (MRI) contrast agents that are responsive to enzyme activity. Enzymes can catalyze a change in water access, rotational tumbling time, the proximity of a 19F- labeled ligand, the aggregation state, the proton chemical-exchange rate between the agent and water, or the chemical shift of 19F, 31P, 13C or a labile 1H of an agent, all of which can be used to detect enzyme activity. The variety of agents attests to the creativity in developing enzyme-responsive MRI contrast agents.

AB - This review focuses on exogenous magnetic resonance imaging (MRI) contrast agents that are responsive to enzyme activity. Enzymes can catalyze a change in water access, rotational tumbling time, the proximity of a 19F- labeled ligand, the aggregation state, the proton chemical-exchange rate between the agent and water, or the chemical shift of 19F, 31P, 13C or a labile 1H of an agent, all of which can be used to detect enzyme activity. The variety of agents attests to the creativity in developing enzyme-responsive MRI contrast agents.

KW - CEST MRI

KW - MR spectroscopy

KW - enzymes

KW - imaging agents

KW - relaxation-based MRI

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Detecting enzyme activities with exogenous MRI contrast agents

Abstract

Keywords

ASJC Scopus subject areas

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